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• W2091926606 abstract "Injury to the central nervous system (CNS) generally results in significant neuronal death and functional loss. In vitro experiments have demonstrated that neurotrophic factors such as brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and neurotrophin-4/5 (NT-4/5) can promote neuronal survival. However, delivery to the injured CNS is difficult as these large protein molecules do not efficiently cross the blood-brain barrier. Intranasal delivery of 70 microg [(125)I]-radiolabeled BDNF, CNTF, NT-4, or erythropoietin (EPO) resulted in 0.1-1.0 nM neurotrophin concentrations within 25 min in brain parenchyma. In addition, not only did these neurotrophic factors reach the CNS, they were present in sufficient concentrations to activate the prosurvival PI3Kinase/Akt pathway, even where lower levels of neurotrophic factors were measured. Currently traumatic, ischemic and compressive injuries to the CNS have no effective treatment. There is potential clinical relevancy of this method for rescuing injured CNS tissues in order to maintain CNS function in affected patients. The intranasal delivery method has great clinical potential due to (1) simplicity of administration, (2) noninvasive drug administration, (3) relatively rapid CNS delivery, (4) ability to repeat dosing easily, (5) no requirement for drug modification, and (6) minimal systemic exposure." @default.
• W2091926606 created "2016-06-24" @default.
• W2091926606 creator A5002159284 @default.
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• W2091926606 creator A5046805860 @default.
• W2091926606 creator A5088195904 @default.
• W2091926606 date "2009-10-06" @default.
• W2091926606 modified "2023-09-23" @default.
• W2091926606 title "Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS" @default.
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• W2091926606 doi "https://doi.org/10.3109/10611860903318134" @default.
• W2091926606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732751" @default.
• W2091926606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19807216" @default.
• W2091926606 hasPublicationYear "2009" @default.
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