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- W2091938246 abstract "<h2>Abstract</h2> <i>Objectives</i>. To assess the antitumor activity of Temozolomide, a novel alkylating agent, in patients with persistent or recurrent ovarian or primary peritoneal carcinoma who have failed other second-line chemotherapy agents. To identify the nature and degree of toxicity of Temozolomide in this group of patients. <i>Methods</i>. Temozolomide was administered orally at an initial dose of 150 mg/m<sup>2</sup> daily for 5 days, every 4 weeks. If the initial course was tolerated without dose-limiting toxicity, then the dose was increased to 200 mg/m<sup>2</sup>. Patients were evaluated for response and toxicity. <i>Results</i>. Fifteen patients were enrolled and evaluated. The median number of prior treatment regimens was 3. Hematologic toxicity was encountered in 26% of patients and was manageable. There were no complete or partial responses. One patient had stable disease with significant improvement in her performance status while on treatment. <i>Conclusion</i>. This dose and schedule of Temozolomide had insignificant activity in this heavily pretreated group of patients with persistent or recurrent ovarian or primary peritoneal carcinoma." @default.
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- W2091938246 date "2004-06-01" @default.
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- W2091938246 title "A phase II evaluation of Temozolomide in patients with recurrent epithelial ovarian cancer" @default.
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- W2091938246 doi "https://doi.org/10.1016/j.ygyno.2004.03.020" @default.
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