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- W2091956415 abstract "During the past 2 decades, the pharmaceutical industry has produced some remarkable medicines to treat human disease by exploiting new discoveries that underpin the pathobiology of specific diseases. For example, insight into the biology of angiotensin II receptors [1] and antitumor necrosis factor [2] led to effective new medicines for the treatment of hypertension and rheumatoid arthritis, respectively. This achievement is remarkable given that of the tens of thousands of compounds screened each year for efficacy, only a fraction survive initial screening and preclinical pharmacology and safety tests, and ultimately survive to undergo clinical trials of efficacy and safety. The process typically requires a decade of development, and costs approach $500 million per drug approved for the U.S. market [3]. As a result of increasing development costs, decreasing success rates of innovative therapeutics, and pending patent expirations for major drug classes, the rate of development of new innovative products is in decline [4]." @default.
- W2091956415 created "2016-06-24" @default.
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- W2091956415 date "2012-06-01" @default.
- W2091956415 modified "2023-10-18" @default.
- W2091956415 title "Increasing Need for Academic Leadership in Clinical Trials" @default.
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- W2091956415 doi "https://doi.org/10.1016/j.pmrj.2012.04.002" @default.
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