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- W2091956950 abstract "The proposal that hypercalcemia of cancer is caused by the ectopic secretion of a parathyroid hormone-like substance has been a riveting hypothesis for the past 50 years.1 We now know that certain solid tumors do synthesize and secrete a polypeptide that has striking biologic similarities to parathyroid hormone.2 This substance, however, is not authentic parathyroid hormone, because parathyroid hormone cannot be detected in the circulation or in tumor tissue. Instead, a substance known as parathyroid hormone-related peptide (PTHRP) is responsible for the biochemical features of hypercalcemia, hypophosphatemia, and elevations in urinary cyclic AMP excretion. The ability of inhibitors of parathyroid . . ." @default.
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- W2091956950 date "1990-04-19" @default.
- W2091956950 modified "2023-10-17" @default.
- W2091956950 title "Parathyroid Hormone–Related Peptide in Sickness and in Health" @default.
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- W2091956950 doi "https://doi.org/10.1056/nejm199004193221610" @default.
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