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• W2091966730 abstract "cis-Platinum (DDP) and cyclophosphamide are commonly used for the treatment of ovarian cancer; however, survival remains poor. The degree of cytotoxicity of the standard antineoplastic agents DDP, 4-hydroperoxy-cyclophosphamide (4-OH-CTX), mitomycin C (MITOM C), vincristine (VCR), etoposide (VP-16), 5-fluorouracil (5-FU), cytosine arabinoside (ARA-C), and interferon (IF) in four representative ovarian cancer cell lines was studied using the ATP assay, which measures total cell kill. Cell lines CAOV-3, OVCAR-3, SKOV-3, and BG-1, which were derived from both pretreated and untreated patients, were exposed to six different concentrations for 90 min. On Day 7, intracellular ATP determinations were done. Sensitivity was defined as ⩾50% cell kill at 0.5× peak plasma concentration as compared to controls. For 4-OH-CTX and ARA-C, 3 and 0.5 μg/ml were chosen as 0.5× reference values. For each drug in each cell line, a highly reproducible dose-response relationship was observed. CAOV-3 cells were sensitive to all drugs except DDP, ARA-C, and IF, and OVCAR-3 cells to all except DDP and IF. SKOV-3 cells were resistant to all agents except VCR, and BG-1 cells to all except MITOM C and 5-FU. The apparent heterogeneic response to antineoplastic agents observed in the above cell lines underscores the importance of assessing individual patients' sensitivity profiles before treatment." @default.
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• W2091966730 date "1990-08-01" @default.
• W2091966730 modified "2023-09-27" @default.
• W2091966730 title "Comparative chemosensitivity profiles in four human ovarian carcinoma cell lines measuring ATP bioluminescence" @default.
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• W2091966730 doi "https://doi.org/10.1016/0090-8258(90)90032-g" @default.
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