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- W2091969811 abstract "The glycolytic rate of cultured neonatal rat cardiac cells was manipulated by varying the concentration of glucose, l-lactate and 2-deoxyglucose supplementing the normal growth medium under anoxic and normoxic conditions. The leakage of lactate dehydrogenase from the cells was found to show good inverse correlation with glycolytic rate under both normoxic and anoxic incubation conditions. Enzyme release correlated inversely with intracellular ATP concentrations in anoxia but not in normoxia. Treatment of cultures with iodoacetate caused enzyme leakage but interference with mitochondrial energy production using cyanide or 2,4-dinitrophenol was without effect on enzyme release. Lactate inhibited fatty acid oxidation in a concentration-dependent manner, but 2-deoxyglucose was without effect. Treatment of cultures with lactate or 2-deoxyglucose caused an increase and a decrease in intracellular fatty acid accumulation, respectively. Elevation of the medium glucose concentration promoted free fatty acid accumulation. Although lactate and 2-deoxyglucose influence fatty acid metabolism by the cardiac cell in different ways they both cause enzyme release, an effect which correlates well with their inhibition of glycolysis even under normoxic conditions." @default.
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- W2091969811 date "1981-06-01" @default.
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- W2091969811 title "The relationship between glycolysis, fatty acid metabolism and membrane integrity in neonatal myocytes" @default.
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- W2091969811 doi "https://doi.org/10.1016/0022-2828(81)90330-8" @default.
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