Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091973604> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2091973604 endingPage "115" @default.
- W2091973604 startingPage "109" @default.
- W2091973604 abstract "The Ca2+ signal is the primary determinant of the contraction of the vascular smooth muscle. However, the alteration of the Ca2+ sensitivity of the contractile apparatus also plays an essential role. The regulation of the myosin light chain phosphatase (MLCP) activity is considered to be the most important mechanism underlying the regulation of Ca2+ sensitivity. The investigations during the last 15 years have identified many proteins that participate in the regulation of the MLCP activity. Recently, the Ca2+ signal has also been shown to cross-talk with the mechanisms regulating the Ca2+ sensitivity. Consequently, Rho kinase, protein kinase C, CPI-17, and MYPT1 have all been suggested to play a physiologically important role in the regulation of the MLCP activity. We are now close to elucidating the major rules regulating the MLCP activity and the Ca2+ sensitivity during vascular contractions. This article will give an overview of the current understanding of the biochemical basis for the regulation of the MLCP activity, while also discussing their functional roles from a physiological point of view. I hope this article will help to develop new pharmacological strategies for the prevention and treatment of the pathological vasoconstriction often seen in vascular diseases." @default.
- W2091973604 created "2016-06-24" @default.
- W2091973604 creator A5035163478 @default.
- W2091973604 date "2007-01-01" @default.
- W2091973604 modified "2023-10-17" @default.
- W2091973604 title "Current Topics in the Regulatory Mechanism Underlying the Ca2+ Sensitization of the Contractile Apparatus in Vascular Smooth Muscle" @default.
- W2091973604 cites W1500244406 @default.
- W2091973604 cites W1517661397 @default.
- W2091973604 cites W1558224598 @default.
- W2091973604 cites W1597787921 @default.
- W2091973604 cites W1967683969 @default.
- W2091973604 cites W1968720947 @default.
- W2091973604 cites W1971461646 @default.
- W2091973604 cites W1985502400 @default.
- W2091973604 cites W1993379452 @default.
- W2091973604 cites W2003033953 @default.
- W2091973604 cites W2003073636 @default.
- W2091973604 cites W2027869462 @default.
- W2091973604 cites W2028018976 @default.
- W2091973604 cites W2032055038 @default.
- W2091973604 cites W2035995170 @default.
- W2091973604 cites W2046191115 @default.
- W2091973604 cites W2067577192 @default.
- W2091973604 cites W2067598924 @default.
- W2091973604 cites W2071701870 @default.
- W2091973604 cites W2081243873 @default.
- W2091973604 cites W2089742414 @default.
- W2091973604 cites W2109354170 @default.
- W2091973604 cites W2130004811 @default.
- W2091973604 cites W2145953966 @default.
- W2091973604 cites W2161583498 @default.
- W2091973604 cites W2254386023 @default.
- W2091973604 cites W4321059465 @default.
- W2091973604 doi "https://doi.org/10.1254/jphs.cp0070027" @default.
- W2091973604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17538233" @default.
- W2091973604 hasPublicationYear "2007" @default.
- W2091973604 type Work @default.
- W2091973604 sameAs 2091973604 @default.
- W2091973604 citedByCount "137" @default.
- W2091973604 countsByYear W20919736042012 @default.
- W2091973604 countsByYear W20919736042013 @default.
- W2091973604 countsByYear W20919736042014 @default.
- W2091973604 countsByYear W20919736042015 @default.
- W2091973604 countsByYear W20919736042016 @default.
- W2091973604 countsByYear W20919736042017 @default.
- W2091973604 countsByYear W20919736042018 @default.
- W2091973604 countsByYear W20919736042019 @default.
- W2091973604 countsByYear W20919736042020 @default.
- W2091973604 countsByYear W20919736042021 @default.
- W2091973604 countsByYear W20919736042022 @default.
- W2091973604 countsByYear W20919736042023 @default.
- W2091973604 crossrefType "journal-article" @default.
- W2091973604 hasAuthorship W2091973604A5035163478 @default.
- W2091973604 hasBestOaLocation W20919736041 @default.
- W2091973604 hasConcept C134018914 @default.
- W2091973604 hasConcept C201800478 @default.
- W2091973604 hasConcept C2779395532 @default.
- W2091973604 hasConcept C2779938346 @default.
- W2091973604 hasConcept C2779961880 @default.
- W2091973604 hasConcept C2992686903 @default.
- W2091973604 hasConcept C62478195 @default.
- W2091973604 hasConcept C6997183 @default.
- W2091973604 hasConcept C8035138 @default.
- W2091973604 hasConcept C86803240 @default.
- W2091973604 hasConcept C95444343 @default.
- W2091973604 hasConceptScore W2091973604C134018914 @default.
- W2091973604 hasConceptScore W2091973604C201800478 @default.
- W2091973604 hasConceptScore W2091973604C2779395532 @default.
- W2091973604 hasConceptScore W2091973604C2779938346 @default.
- W2091973604 hasConceptScore W2091973604C2779961880 @default.
- W2091973604 hasConceptScore W2091973604C2992686903 @default.
- W2091973604 hasConceptScore W2091973604C62478195 @default.
- W2091973604 hasConceptScore W2091973604C6997183 @default.
- W2091973604 hasConceptScore W2091973604C8035138 @default.
- W2091973604 hasConceptScore W2091973604C86803240 @default.
- W2091973604 hasConceptScore W2091973604C95444343 @default.
- W2091973604 hasIssue "2" @default.
- W2091973604 hasLocation W20919736041 @default.
- W2091973604 hasLocation W20919736042 @default.
- W2091973604 hasOpenAccess W2091973604 @default.
- W2091973604 hasPrimaryLocation W20919736041 @default.
- W2091973604 hasRelatedWork W1989762999 @default.
- W2091973604 hasRelatedWork W1991499316 @default.
- W2091973604 hasRelatedWork W1992343876 @default.
- W2091973604 hasRelatedWork W1997242049 @default.
- W2091973604 hasRelatedWork W2051402580 @default.
- W2091973604 hasRelatedWork W2091508582 @default.
- W2091973604 hasRelatedWork W2128829568 @default.
- W2091973604 hasRelatedWork W2885359423 @default.
- W2091973604 hasRelatedWork W3105739081 @default.
- W2091973604 hasRelatedWork W4236025656 @default.
- W2091973604 hasVolume "104" @default.
- W2091973604 isParatext "false" @default.
- W2091973604 isRetracted "false" @default.
- W2091973604 magId "2091973604" @default.
- W2091973604 workType "article" @default.