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- W2091976584 abstract "In The Lancet today, Paul Noble and colleagues report the results of the CAPACITY programme (Clinical Studies Assessing Pirfenidone in idiopathic pulmonary fibrosis: Research of Efficacy and Safety Outcomes). 1 Noble PW Albera C Bradford WZ et al. for the CAPACITY Study GroupPirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. Lancet. 2011; (published online May 14.)https://doi.org/10.1016/S0140-6736(11)60405-4 Summary Full Text Full Text PDF PubMed Scopus (1449) Google Scholar Two concurrent phase 3 clinical trials (studies 004 and 006) investigated the role of pirfenidone in patients with mild-to-moderate idiopathic pulmonary fibrosis (ie, forced vital capacity [FVC] ≥50% predicted, and diffusing capacity of the lung for carbon monoxide ≥35% predicted). Patients were randomly assigned blinded treatment with oral pirfenidone or placebo for a minimum of 72 weeks. In study 004, 174 patients were assigned a high drug dose (pirfenidone 2403 mg/day), 87 patients a low drug dose (pirfenidone 1197 mg/day), and 174 placebo; in study 006, 171 patients were assigned the same high dose and 173 patients placebo. The primary endpoint was change in percentage predicted FVC at week 72. Secondary endpoints included progression-free survival and 6-min walk-test (6MWT) distance. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trialsThe data show pirfenidone has a favourable benefit risk profile and represents an appropriate treatment option for patients with idiopathic pulmonary fibrosis. Full-Text PDF" @default.
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- W2091976584 date "2011-05-01" @default.
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- W2091976584 title "Pirfenidone for idiopathic pulmonary fibrosis" @default.
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- W2091976584 doi "https://doi.org/10.1016/s0140-6736(11)60546-1" @default.
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