FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091985992> ?p ?o ?g. }

• W2091985992 endingPage "669" @default.
• W2091985992 startingPage "661" @default.
• W2091985992 abstract "Our previous studies showed that Aflatoxin G1 (AFG1) could induce lung adenocarcinoma, and that the cancer cells originated from alveolar type II cells (AT-II cells). Recently, we found AFG1 induced structural impairment in rat AT-II cells, which may account for an early event in lung tumorigenesis. However, the mechanism of AFG1-induced AT-II cell damage remains unclear. DNA damage and apoptosis induced by oxidative stress are well accepted causes of cell damage. Thus, we explore whether AFG1 activates the reactive oxygen species (ROS)/MAPK/apoptosis pathway to cause cell damage in human AT-II cells like the cell line (A549). We found AFG1 induced oxidative stress by increasing ROS generation and caused DNA double-strand breaks (DSBs) by up-regulating γH2AX expression. AFG1 also triggered apoptosis in A549 cells by regulating Fas/FasL, caspase-8, Bax, Bcl-2, and activating caspase-3. Pre-treatment with antioxidant n-acetyl-l-cysteine (NAC) reduced ROS generation and DNA DSBs, inhibited apoptosis, and increased cell viability in AFG1-treated cells. Furthermore, we found AFG1 activated ROS-mediated JNK and p38 pathways to induce cell apoptosis in A549 cells. In conclusion, our results indicate that AFG1 induces oxidative DNA damage and triggers apoptosis through ROS-mediated JNK and p38 signaling pathways in A549 cells, which may contribute to AFG1-induced AT-II cell damage." @default.
• W2091985992 created "2016-06-24" @default.
• W2091985992 creator A5014127664 @default.
• W2091985992 creator A5016013376 @default.
• W2091985992 creator A5017774638 @default.
• W2091985992 creator A5018892762 @default.
• W2091985992 creator A5034709783 @default.
• W2091985992 creator A5035275013 @default.
• W2091985992 creator A5035282947 @default.
• W2091985992 creator A5054545129 @default.
• W2091985992 creator A5078887137 @default.
• W2091985992 date "2013-12-01" @default.
• W2091985992 modified "2023-10-18" @default.
• W2091985992 title "Aflatoxin G1-induced oxidative stress causes DNA damage and triggers apoptosis through MAPK signaling pathway in A549 cells" @default.
• W2091985992 cites W1811191752 @default.
• W2091985992 cites W1845321470 @default.
• W2091985992 cites W1963721113 @default.
• W2091985992 cites W1968785692 @default.
• W2091985992 cites W1975648786 @default.
• W2091985992 cites W1976340581 @default.
• W2091985992 cites W1978730384 @default.
• W2091985992 cites W1985153440 @default.
• W2091985992 cites W1985542149 @default.
• W2091985992 cites W1989884334 @default.
• W2091985992 cites W1991090990 @default.
• W2091985992 cites W1994288564 @default.
• W2091985992 cites W202261485 @default.
• W2091985992 cites W2023169350 @default.
• W2091985992 cites W2029367870 @default.
• W2091985992 cites W2029627480 @default.
• W2091985992 cites W2035188915 @default.
• W2091985992 cites W2037535424 @default.
• W2091985992 cites W2038552318 @default.
• W2091985992 cites W2039085372 @default.
• W2091985992 cites W2043448076 @default.
• W2091985992 cites W2044845610 @default.
• W2091985992 cites W2052727997 @default.
• W2091985992 cites W2061047542 @default.
• W2091985992 cites W2062880851 @default.
• W2091985992 cites W2073806713 @default.
• W2091985992 cites W2075603898 @default.
• W2091985992 cites W2076762694 @default.
• W2091985992 cites W2081499110 @default.
• W2091985992 cites W2083262462 @default.
• W2091985992 cites W2087990966 @default.
• W2091985992 cites W2093383037 @default.
• W2091985992 cites W2101204394 @default.
• W2091985992 cites W2117975450 @default.
• W2091985992 cites W2120677731 @default.
• W2091985992 cites W2127371200 @default.
• W2091985992 cites W2129953000 @default.
• W2091985992 cites W2132461409 @default.
• W2091985992 cites W2135431604 @default.
• W2091985992 cites W2143662196 @default.
• W2091985992 cites W2146085143 @default.
• W2091985992 cites W2146965545 @default.
• W2091985992 cites W2158380484 @default.
• W2091985992 cites W2169827914 @default.
• W2091985992 doi "https://doi.org/10.1016/j.fct.2013.09.030" @default.
• W2091985992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24090735" @default.
• W2091985992 hasPublicationYear "2013" @default.
• W2091985992 type Work @default.
• W2091985992 sameAs 2091985992 @default.
• W2091985992 citedByCount "38" @default.
• W2091985992 countsByYear W20919859922014 @default.
• W2091985992 countsByYear W20919859922015 @default.
• W2091985992 countsByYear W20919859922016 @default.
• W2091985992 countsByYear W20919859922017 @default.
• W2091985992 countsByYear W20919859922018 @default.
• W2091985992 countsByYear W20919859922020 @default.
• W2091985992 countsByYear W20919859922021 @default.
• W2091985992 countsByYear W20919859922022 @default.
• W2091985992 countsByYear W20919859922023 @default.
• W2091985992 crossrefType "journal-article" @default.
• W2091985992 hasAuthorship W2091985992A5014127664 @default.
• W2091985992 hasAuthorship W2091985992A5016013376 @default.
• W2091985992 hasAuthorship W2091985992A5017774638 @default.
• W2091985992 hasAuthorship W2091985992A5018892762 @default.
• W2091985992 hasAuthorship W2091985992A5034709783 @default.
• W2091985992 hasAuthorship W2091985992A5035275013 @default.
• W2091985992 hasAuthorship W2091985992A5035282947 @default.
• W2091985992 hasAuthorship W2091985992A5054545129 @default.
• W2091985992 hasAuthorship W2091985992A5078887137 @default.
• W2091985992 hasConcept C104317684 @default.
• W2091985992 hasConcept C143425029 @default.
• W2091985992 hasConcept C185592680 @default.
• W2091985992 hasConcept C190283241 @default.
• W2091985992 hasConcept C2776151105 @default.
• W2091985992 hasConcept C48349386 @default.
• W2091985992 hasConcept C552990157 @default.
• W2091985992 hasConcept C55493867 @default.
• W2091985992 hasConcept C555283112 @default.
• W2091985992 hasConcept C57074206 @default.
• W2091985992 hasConcept C62478195 @default.
• W2091985992 hasConcept C81729549 @default.
• W2091985992 hasConcept C86803240 @default.
• W2091985992 hasConcept C95444343 @default.
• W2091985992 hasConceptScore W2091985992C104317684 @default.

• next