FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091986411> ?p ?o ?g. }

• W2091986411 endingPage "125" @default.
• W2091986411 startingPage "116" @default.
• W2091986411 abstract "Regulators of the mitotic spindle apparatus are attractive cellular targets for antitumor therapy. The centrosomal protein transforming acidic coiled coil (TACC) 3 is required for spindle assembly and proper chromosome segregation. In this study, we employed an inducible RNA interference approach to downregulate TACC3 expression. We show that TACC3 knock-down in NIH3T3 fibroblasts caused aneuploidy, but failed to overtly impair mitotic progression. TACC3 depletion rather triggered a postmitotic p53–p21WAF pathway and led to a reversible cell cycle arrest. Similar effects were induced by low concentrations of paclitaxel, a spindle poison used in antitumor therapy. Interestingly, however, and unlike in TACC3-proficient cells, paclitaxel was able to induce strong polyploidy and subsequent apoptosis in TACC3-depleted cells. Even though paclitaxel treatment was associated with the activation of the survival kinase Akt and an antiapoptotic expression of cytoplasmic p21WAF and cyclin D1, this inhibition of cell death was abrogated by depletion of TACC3. Thus, our data identify TACC3 as a potential target to overcome p21WAF-associated protection of transformed cells against paclitaxel-induced cell death." @default.
• W2091986411 created "2016-06-24" @default.
• W2091986411 creator A5017306949 @default.
• W2091986411 creator A5017322730 @default.
• W2091986411 creator A5017428199 @default.
• W2091986411 creator A5027794047 @default.
• W2091986411 creator A5040511454 @default.
• W2091986411 creator A5061715630 @default.
• W2091986411 creator A5066952869 @default.
• W2091986411 creator A5074047222 @default.
• W2091986411 date "2007-06-25" @default.
• W2091986411 modified "2023-10-15" @default.
• W2091986411 title "TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest" @default.
• W2091986411 cites W173079764 @default.
• W2091986411 cites W1964740588 @default.
• W2091986411 cites W1967835084 @default.
• W2091986411 cites W1967880683 @default.
• W2091986411 cites W1971579914 @default.
• W2091986411 cites W1972305847 @default.
• W2091986411 cites W1985697607 @default.
• W2091986411 cites W1990118065 @default.
• W2091986411 cites W2006351736 @default.
• W2091986411 cites W2012877669 @default.
• W2091986411 cites W2015616869 @default.
• W2091986411 cites W2020431095 @default.
• W2091986411 cites W2034086671 @default.
• W2091986411 cites W2037248589 @default.
• W2091986411 cites W2042921949 @default.
• W2091986411 cites W2046088362 @default.
• W2091986411 cites W2047533536 @default.
• W2091986411 cites W2059809467 @default.
• W2091986411 cites W2065919583 @default.
• W2091986411 cites W2065955521 @default.
• W2091986411 cites W2069348059 @default.
• W2091986411 cites W2072720547 @default.
• W2091986411 cites W2073963296 @default.
• W2091986411 cites W2081029482 @default.
• W2091986411 cites W2082169879 @default.
• W2091986411 cites W2085833148 @default.
• W2091986411 cites W2086098062 @default.
• W2091986411 cites W2089964771 @default.
• W2091986411 cites W2099990067 @default.
• W2091986411 cites W2124809046 @default.
• W2091986411 cites W2132661761 @default.
• W2091986411 cites W2133591190 @default.
• W2091986411 cites W2135645995 @default.
• W2091986411 cites W2143464168 @default.
• W2091986411 cites W2162281878 @default.
• W2091986411 cites W2164778107 @default.
• W2091986411 cites W2171217566 @default.
• W2091986411 cites W2253380896 @default.
• W2091986411 cites W2325740123 @default.
• W2091986411 cites W2333925163 @default.
• W2091986411 cites W4253627433 @default.
• W2091986411 doi "https://doi.org/10.1038/sj.onc.1210628" @default.
• W2091986411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17599038" @default.
• W2091986411 hasPublicationYear "2007" @default.
• W2091986411 type Work @default.
• W2091986411 sameAs 2091986411 @default.
• W2091986411 citedByCount "34" @default.
• W2091986411 countsByYear W20919864112012 @default.
• W2091986411 countsByYear W20919864112013 @default.
• W2091986411 countsByYear W20919864112014 @default.
• W2091986411 countsByYear W20919864112015 @default.
• W2091986411 countsByYear W20919864112016 @default.
• W2091986411 countsByYear W20919864112017 @default.
• W2091986411 countsByYear W20919864112018 @default.
• W2091986411 countsByYear W20919864112020 @default.
• W2091986411 countsByYear W20919864112021 @default.
• W2091986411 countsByYear W20919864112022 @default.
• W2091986411 countsByYear W20919864112023 @default.
• W2091986411 crossrefType "journal-article" @default.
• W2091986411 hasAuthorship W2091986411A5017306949 @default.
• W2091986411 hasAuthorship W2091986411A5017322730 @default.
• W2091986411 hasAuthorship W2091986411A5017428199 @default.
• W2091986411 hasAuthorship W2091986411A5027794047 @default.
• W2091986411 hasAuthorship W2091986411A5040511454 @default.
• W2091986411 hasAuthorship W2091986411A5061715630 @default.
• W2091986411 hasAuthorship W2091986411A5066952869 @default.
• W2091986411 hasAuthorship W2091986411A5074047222 @default.
• W2091986411 hasBestOaLocation W20919864111 @default.
• W2091986411 hasConcept C104317684 @default.
• W2091986411 hasConcept C10447061 @default.
• W2091986411 hasConcept C105696609 @default.
• W2091986411 hasConcept C120504264 @default.
• W2091986411 hasConcept C121608353 @default.
• W2091986411 hasConcept C127561419 @default.
• W2091986411 hasConcept C1491633281 @default.
• W2091986411 hasConcept C175732170 @default.
• W2091986411 hasConcept C186000732 @default.
• W2091986411 hasConcept C190283241 @default.
• W2091986411 hasConcept C199835354 @default.
• W2091986411 hasConcept C2777292972 @default.
• W2091986411 hasConcept C2778437423 @default.
• W2091986411 hasConcept C2911011838 @default.
• W2091986411 hasConcept C29537977 @default.
• W2091986411 hasConcept C31573885 @default.
• W2091986411 hasConcept C3453395 @default.

• next