Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091997777> ?p ?o ?g. }
- W2091997777 endingPage "689" @default.
- W2091997777 startingPage "683" @default.
- W2091997777 abstract "Agouti-related protein (AGRP) is a naturally occurring antagonist of the brain melanocortin receptors (MC3R and MC4R) and is physiologically implicated as participating in feeding behavior and energy homeostasis. The human AGRP decapeptide Yc[CRFFNAFC]Y has been previously reported as binding to the human MC3 and MC4 receptors and antagonizing the MC4 receptor. We have synthesized this decapeptide and pharmacologically characterized it at the murine melanocortin receptors and found it to possess MC4R antagonist activity (pA2 = 6.8) and, unexpectedly, MC1R agonist activity (EC50 = 2.89 μM). This study characterizes the first AGRP-based peptide agonist at the melanocortin receptors." @default.
- W2091997777 created "2016-06-24" @default.
- W2091997777 creator A5042605396 @default.
- W2091997777 creator A5052534823 @default.
- W2091997777 creator A5071817565 @default.
- W2091997777 creator A5087487462 @default.
- W2091997777 date "2000-05-01" @default.
- W2091997777 modified "2023-10-18" @default.
- W2091997777 title "The agouti-related protein decapeptide (Yc[CRFFNAFC]Y) possesses agonist activity at the murine melanocortin-1 receptor" @default.
- W2091997777 cites W1549372716 @default.
- W2091997777 cites W1566308385 @default.
- W2091997777 cites W1881247801 @default.
- W2091997777 cites W1964488668 @default.
- W2091997777 cites W1966362498 @default.
- W2091997777 cites W1979420492 @default.
- W2091997777 cites W1983559681 @default.
- W2091997777 cites W1986858551 @default.
- W2091997777 cites W1990332976 @default.
- W2091997777 cites W1990492207 @default.
- W2091997777 cites W1998952334 @default.
- W2091997777 cites W2001411045 @default.
- W2091997777 cites W2010142606 @default.
- W2091997777 cites W2014375899 @default.
- W2091997777 cites W2015370922 @default.
- W2091997777 cites W2015986042 @default.
- W2091997777 cites W2018085228 @default.
- W2091997777 cites W2028918996 @default.
- W2091997777 cites W2042658226 @default.
- W2091997777 cites W2045664576 @default.
- W2091997777 cites W2061240699 @default.
- W2091997777 cites W2061576647 @default.
- W2091997777 cites W2065389660 @default.
- W2091997777 cites W2066655086 @default.
- W2091997777 cites W2072752637 @default.
- W2091997777 cites W2083116048 @default.
- W2091997777 cites W2084547258 @default.
- W2091997777 cites W2090409852 @default.
- W2091997777 cites W2094828639 @default.
- W2091997777 cites W2101852419 @default.
- W2091997777 cites W2102568364 @default.
- W2091997777 cites W2105470099 @default.
- W2091997777 cites W2144969564 @default.
- W2091997777 cites W2153867200 @default.
- W2091997777 cites W2162394145 @default.
- W2091997777 cites W2262298293 @default.
- W2091997777 cites W4236354806 @default.
- W2091997777 cites W4237255555 @default.
- W2091997777 cites W4238499560 @default.
- W2091997777 cites W4251169201 @default.
- W2091997777 cites W4256109724 @default.
- W2091997777 doi "https://doi.org/10.1016/s0196-9781(00)00194-7" @default.
- W2091997777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10876051" @default.
- W2091997777 hasPublicationYear "2000" @default.
- W2091997777 type Work @default.
- W2091997777 sameAs 2091997777 @default.
- W2091997777 citedByCount "20" @default.
- W2091997777 countsByYear W20919977772014 @default.
- W2091997777 countsByYear W20919977772015 @default.
- W2091997777 countsByYear W20919977772017 @default.
- W2091997777 countsByYear W20919977772018 @default.
- W2091997777 countsByYear W20919977772020 @default.
- W2091997777 countsByYear W20919977772021 @default.
- W2091997777 crossrefType "journal-article" @default.
- W2091997777 hasAuthorship W2091997777A5042605396 @default.
- W2091997777 hasAuthorship W2091997777A5052534823 @default.
- W2091997777 hasAuthorship W2091997777A5071817565 @default.
- W2091997777 hasAuthorship W2091997777A5087487462 @default.
- W2091997777 hasConcept C126322002 @default.
- W2091997777 hasConcept C134018914 @default.
- W2091997777 hasConcept C135285700 @default.
- W2091997777 hasConcept C170493617 @default.
- W2091997777 hasConcept C185592680 @default.
- W2091997777 hasConcept C2491326 @default.
- W2091997777 hasConcept C2776885963 @default.
- W2091997777 hasConcept C2777241137 @default.
- W2091997777 hasConcept C2778938600 @default.
- W2091997777 hasConcept C2779993316 @default.
- W2091997777 hasConcept C43295716 @default.
- W2091997777 hasConcept C43790157 @default.
- W2091997777 hasConcept C55493867 @default.
- W2091997777 hasConcept C58732023 @default.
- W2091997777 hasConcept C71924100 @default.
- W2091997777 hasConcept C86803240 @default.
- W2091997777 hasConcept C98274493 @default.
- W2091997777 hasConceptScore W2091997777C126322002 @default.
- W2091997777 hasConceptScore W2091997777C134018914 @default.
- W2091997777 hasConceptScore W2091997777C135285700 @default.
- W2091997777 hasConceptScore W2091997777C170493617 @default.
- W2091997777 hasConceptScore W2091997777C185592680 @default.
- W2091997777 hasConceptScore W2091997777C2491326 @default.
- W2091997777 hasConceptScore W2091997777C2776885963 @default.
- W2091997777 hasConceptScore W2091997777C2777241137 @default.
- W2091997777 hasConceptScore W2091997777C2778938600 @default.
- W2091997777 hasConceptScore W2091997777C2779993316 @default.
- W2091997777 hasConceptScore W2091997777C43295716 @default.
- W2091997777 hasConceptScore W2091997777C43790157 @default.
- W2091997777 hasConceptScore W2091997777C55493867 @default.
- W2091997777 hasConceptScore W2091997777C58732023 @default.