FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091997915> ?p ?o ?g. }

• W2091997915 endingPage "352" @default.
• W2091997915 startingPage "339" @default.
• W2091997915 abstract "Aristolochic acids I and II (AA-I, AA-II) are found in all Aristolochia species. Ingestion of these acids either in the form of herbal remedies or as contaminated wheat flour causes a dose-dependent chronic kidney failure characterized by renal tubulointerstitial fibrosis. In ∼50% of these cases, the condition is accompanied by an upper urinary tract malignancy. The disease is now termed aristolochic acid nephropathy (AAN). AA-I is largely responsible for the nephrotoxicity while both AA-I and AA-II are genotoxic. DNA adducts derived from AA-I and AA-II have been isolated from renal tissues of patients suffering from AAN. We describe the total synthesis, de novo, of the dA and dG adducts derived from AA-II, their incorporation site-specifically into DNA oligomers and the splicing of these modified oligomers into a plasmid construct followed by transfection into mouse embryonic fibroblasts. Analysis of the plasmid progeny revealed that both adducts blocked replication but were still partly processed by DNA polymerase(s). Although the majority of coding events involved insertion of correct nucleotides, substantial misincorporation of bases also was noted. The dA adduct is significantly more mutagenic than the dG adduct; both adducts give rise, almost exclusively, to misincorporation of dA, which leads to AL-II-dA→T and AL-II-dG→T transversions." @default.
• W2091997915 created "2016-06-24" @default.
• W2091997915 creator A5004022487 @default.
• W2091997915 creator A5005834490 @default.
• W2091997915 creator A5033638378 @default.
• W2091997915 creator A5038844717 @default.
• W2091997915 creator A5040952341 @default.
• W2091997915 creator A5043432273 @default.
• W2091997915 creator A5064458848 @default.
• W2091997915 creator A5073612305 @default.
• W2091997915 creator A5074452031 @default.
• W2091997915 date "2009-10-23" @default.
• W2091997915 modified "2023-09-27" @default.
• W2091997915 title "DNA adducts of aristolochic acid II: total synthesis and site-specific mutagenesis studies in mammalian cells" @default.
• W2091997915 cites W1967446284 @default.
• W2091997915 cites W1968353327 @default.
• W2091997915 cites W1971688048 @default.
• W2091997915 cites W1975840258 @default.
• W2091997915 cites W1977199149 @default.
• W2091997915 cites W1980205917 @default.
• W2091997915 cites W1994104924 @default.
• W2091997915 cites W1995985392 @default.
• W2091997915 cites W2001364126 @default.
• W2091997915 cites W2013827205 @default.
• W2091997915 cites W2015826273 @default.
• W2091997915 cites W2018086514 @default.
• W2091997915 cites W2033089404 @default.
• W2091997915 cites W2038341795 @default.
• W2091997915 cites W2039163337 @default.
• W2091997915 cites W2040645002 @default.
• W2091997915 cites W2042028754 @default.
• W2091997915 cites W2043296545 @default.
• W2091997915 cites W2045318949 @default.
• W2091997915 cites W2047244088 @default.
• W2091997915 cites W2050958285 @default.
• W2091997915 cites W2063768393 @default.
• W2091997915 cites W2072828753 @default.
• W2091997915 cites W2077122464 @default.
• W2091997915 cites W2090024127 @default.
• W2091997915 cites W2090093965 @default.
• W2091997915 cites W2096285448 @default.
• W2091997915 cites W2100204093 @default.
• W2091997915 cites W2120221084 @default.
• W2091997915 cites W2124581521 @default.
• W2091997915 cites W2124903568 @default.
• W2091997915 cites W2139640448 @default.
• W2091997915 cites W2146395343 @default.
• W2091997915 cites W2162463986 @default.
• W2091997915 cites W2321597988 @default.
• W2091997915 cites W2332392131 @default.
• W2091997915 cites W2949357833 @default.
• W2091997915 cites W2951605818 @default.
• W2091997915 cites W3142714722 @default.
• W2091997915 cites W4255014350 @default.
• W2091997915 cites W4256224217 @default.
• W2091997915 cites W969951715 @default.
• W2091997915 doi "https://doi.org/10.1093/nar/gkp815" @default.
• W2091997915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2800210" @default.
• W2091997915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19854934" @default.
• W2091997915 hasPublicationYear "2009" @default.
• W2091997915 type Work @default.
• W2091997915 sameAs 2091997915 @default.
• W2091997915 citedByCount "65" @default.
• W2091997915 countsByYear W20919979152012 @default.
• W2091997915 countsByYear W20919979152013 @default.
• W2091997915 countsByYear W20919979152014 @default.
• W2091997915 countsByYear W20919979152015 @default.
• W2091997915 countsByYear W20919979152016 @default.
• W2091997915 countsByYear W20919979152017 @default.
• W2091997915 countsByYear W20919979152018 @default.
• W2091997915 countsByYear W20919979152019 @default.
• W2091997915 countsByYear W20919979152020 @default.
• W2091997915 countsByYear W20919979152021 @default.
• W2091997915 countsByYear W20919979152022 @default.
• W2091997915 countsByYear W20919979152023 @default.
• W2091997915 crossrefType "journal-article" @default.
• W2091997915 hasAuthorship W2091997915A5004022487 @default.
• W2091997915 hasAuthorship W2091997915A5005834490 @default.
• W2091997915 hasAuthorship W2091997915A5033638378 @default.
• W2091997915 hasAuthorship W2091997915A5038844717 @default.
• W2091997915 hasAuthorship W2091997915A5040952341 @default.
• W2091997915 hasAuthorship W2091997915A5043432273 @default.
• W2091997915 hasAuthorship W2091997915A5064458848 @default.
• W2091997915 hasAuthorship W2091997915A5073612305 @default.
• W2091997915 hasAuthorship W2091997915A5074452031 @default.
• W2091997915 hasBestOaLocation W20919979151 @default.
• W2091997915 hasConcept C104317684 @default.
• W2091997915 hasConcept C108204754 @default.
• W2091997915 hasConcept C114246631 @default.
• W2091997915 hasConcept C126189478 @default.
• W2091997915 hasConcept C153911025 @default.
• W2091997915 hasConcept C16318435 @default.
• W2091997915 hasConcept C178790620 @default.
• W2091997915 hasConcept C185592680 @default.
• W2091997915 hasConcept C18903297 @default.
• W2091997915 hasConcept C2777993478 @default.
• W2091997915 hasConcept C2780091579 @default.
• W2091997915 hasConcept C2780813843 @default.

• next