FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092000809> ?p ?o ?g. }

• W2092000809 endingPage "521" @default.
• W2092000809 startingPage "513" @default.
• W2092000809 abstract "The purpose of this work was to gain insight into the role played by platelets and endothelial cells in the development of thrombogenic vascular events, observed after in vivo photodynamic therapy (PDT), by studying the in vitro effects of PDT on isolated human platelets and cultured human and bovine endothelial cells. Exposure to Photofrin II (PII) and light caused platelets to rapidly lose their ability to aggregate. Photofrin II alone at high concentrations also exerted inhibitory effects on aggregation. Endothelial cells exposed to PII- and phthalocyanine (GaCI-PcS2,3 or Zn-PCS1,2)-mediated PDT released potent platelet anti- and disaggregating activity which could be identified as prostacyclin by the following criteria: a close correlation between the time and dose dependent anti-aggregating effects and released 6-keto-PGF1α (the spontaneous hydrolysis praduct of PGI, determined by radioimmunoassay), the inhibition of these effects by indomethacin, accumulation of 6-keto-PGF1α metabolite in the media of cells treated with PDT (as determined by HPLC analysis), and the absence of evidence for significant nitric oxide production. This prostacyclin release occurred following plasma membrane damage. Although no pro-aggregating activity was observed, endothelial cells were found to release considerable amounts of arachidonic acid and prostaglandin F2α in response to PDT. These data, which indicate powerful anti-thrombogenic effects in vitro, are in sharp contrast to the vascular effects of PDT in vivo which are characterized by severe platelet aggregation, and imply that the in vivo effects involve additional components of the vascular system." @default.
• W2092000809 created "2016-06-24" @default.
• W2092000809 creator A5006921382 @default.
• W2092000809 creator A5015928826 @default.
• W2092000809 creator A5043042500 @default.
• W2092000809 creator A5070636742 @default.
• W2092000809 date "1992-10-01" @default.
• W2092000809 modified "2023-10-18" @default.
• W2092000809 title "EFFECTS OF PHOTODYNAMIC TREATMENT OF PLATELETS OR ENDOTHELIAL CELLS in vitro ON PLATELET AGGREGATION" @default.
• W2092000809 cites W1513774612 @default.
• W2092000809 cites W1807744336 @default.
• W2092000809 cites W1965417960 @default.
• W2092000809 cites W1975435918 @default.
• W2092000809 cites W1989029706 @default.
• W2092000809 cites W1990802251 @default.
• W2092000809 cites W1997324943 @default.
• W2092000809 cites W2006068735 @default.
• W2092000809 cites W2007832676 @default.
• W2092000809 cites W2013773745 @default.
• W2092000809 cites W2018260864 @default.
• W2092000809 cites W2064926424 @default.
• W2092000809 cites W2077113507 @default.
• W2092000809 cites W2084727733 @default.
• W2092000809 cites W2091210609 @default.
• W2092000809 cites W2104380573 @default.
• W2092000809 cites W2107948155 @default.
• W2092000809 cites W2126624423 @default.
• W2092000809 cites W2144663935 @default.
• W2092000809 cites W2315420377 @default.
• W2092000809 cites W2327135194 @default.
• W2092000809 cites W2396847665 @default.
• W2092000809 doi "https://doi.org/10.1111/j.1751-1097.1992.tb02195.x" @default.
• W2092000809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1454881" @default.
• W2092000809 hasPublicationYear "1992" @default.
• W2092000809 type Work @default.
• W2092000809 sameAs 2092000809 @default.
• W2092000809 citedByCount "36" @default.
• W2092000809 countsByYear W20920008092012 @default.
• W2092000809 countsByYear W20920008092013 @default.
• W2092000809 countsByYear W20920008092014 @default.
• W2092000809 countsByYear W20920008092015 @default.
• W2092000809 countsByYear W20920008092017 @default.
• W2092000809 countsByYear W20920008092020 @default.
• W2092000809 countsByYear W20920008092021 @default.
• W2092000809 crossrefType "journal-article" @default.
• W2092000809 hasAuthorship W2092000809A5006921382 @default.
• W2092000809 hasAuthorship W2092000809A5015928826 @default.
• W2092000809 hasAuthorship W2092000809A5043042500 @default.
• W2092000809 hasAuthorship W2092000809A5070636742 @default.
• W2092000809 hasConcept C126322002 @default.
• W2092000809 hasConcept C150903083 @default.
• W2092000809 hasConcept C178790620 @default.
• W2092000809 hasConcept C181199279 @default.
• W2092000809 hasConcept C185592680 @default.
• W2092000809 hasConcept C202751555 @default.
• W2092000809 hasConcept C207001950 @default.
• W2092000809 hasConcept C2777477808 @default.
• W2092000809 hasConcept C2778078955 @default.
• W2092000809 hasConcept C2780664492 @default.
• W2092000809 hasConcept C2781128415 @default.
• W2092000809 hasConcept C519581460 @default.
• W2092000809 hasConcept C55493867 @default.
• W2092000809 hasConcept C71924100 @default.
• W2092000809 hasConcept C86803240 @default.
• W2092000809 hasConcept C89560881 @default.
• W2092000809 hasConcept C98274493 @default.
• W2092000809 hasConceptScore W2092000809C126322002 @default.
• W2092000809 hasConceptScore W2092000809C150903083 @default.
• W2092000809 hasConceptScore W2092000809C178790620 @default.
• W2092000809 hasConceptScore W2092000809C181199279 @default.
• W2092000809 hasConceptScore W2092000809C185592680 @default.
• W2092000809 hasConceptScore W2092000809C202751555 @default.
• W2092000809 hasConceptScore W2092000809C207001950 @default.
• W2092000809 hasConceptScore W2092000809C2777477808 @default.
• W2092000809 hasConceptScore W2092000809C2778078955 @default.
• W2092000809 hasConceptScore W2092000809C2780664492 @default.
• W2092000809 hasConceptScore W2092000809C2781128415 @default.
• W2092000809 hasConceptScore W2092000809C519581460 @default.
• W2092000809 hasConceptScore W2092000809C55493867 @default.
• W2092000809 hasConceptScore W2092000809C71924100 @default.
• W2092000809 hasConceptScore W2092000809C86803240 @default.
• W2092000809 hasConceptScore W2092000809C89560881 @default.
• W2092000809 hasConceptScore W2092000809C98274493 @default.
• W2092000809 hasIssue "4" @default.
• W2092000809 hasLocation W20920008091 @default.
• W2092000809 hasLocation W20920008092 @default.
• W2092000809 hasOpenAccess W2092000809 @default.
• W2092000809 hasPrimaryLocation W20920008091 @default.
• W2092000809 hasRelatedWork W1585103028 @default.
• W2092000809 hasRelatedWork W1597979925 @default.
• W2092000809 hasRelatedWork W1929166947 @default.
• W2092000809 hasRelatedWork W2039123883 @default.
• W2092000809 hasRelatedWork W2041471231 @default.
• W2092000809 hasRelatedWork W2051241718 @default.
• W2092000809 hasRelatedWork W2067386383 @default.
• W2092000809 hasRelatedWork W2077399237 @default.
• W2092000809 hasRelatedWork W2083118160 @default.
• W2092000809 hasRelatedWork W2141285413 @default.

• next