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- W2092012247 abstract "Expression of the polyoma virus middle T antigen in HL-60 cells accelerates their differentiation in response to both monocytic and granulocytic differentiation-inducing agents. Middle T-expressing cells treated with the granulocytic inducer retinoic acid or the monocytic inducer 1,25-dihydroxy vitamin D3 differentiated 24 h earlier than parental, mock-electroporated, or vector control cell lines. The rapid onset of differentiation correlated with an increase in the cellular level of the middle T protein as well as two known retinoic-acid-inducible markers in HL-60 cells: the paxillin and transglutaminase gene products. The accelerated functional differentiation response and expression of retinoic-acid-inducible markers indicate that middle T played a causal role in differentiation. Thus, expression of the polyoma middle T antigen in HL-60 cells enhanced a variety of molecular changes associated with cellular differentiation." @default.
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- W2092012247 date "1998-01-01" @default.
- W2092012247 modified "2023-09-27" @default.
- W2092012247 title "Polyoma Middle T Antigen in HL-60 Cells Accelerates Hematopoietic Myeloid and Monocytic Cell Differentiation" @default.
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- W2092012247 doi "https://doi.org/10.1006/excr.1997.3782" @default.
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