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• W2092019411 endingPage "47" @default.
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• W2092019411 abstract "We have developed a novel, electrophysiologically intact and light-sensitive “inside-out” cell model (IOCM) of microvillar photoreceptors of the leech Hirudo medicinalis. Light responses recorded from the IOCM with sharp microelectrodes are depolarizations with amplitudes of up to 50–60 mV. In darkness, graded elevations of the free Ca2+ concentration in the “intracellular medium” (ICM) reversibly increase the conductance of the microvillar membrane leading to Ca2+-induced graded voltage changes up to ∼50 mV. The threshold for Ca2+-induced voltage changes is ∼0.06 μM, EC50 is ∼1.2 μM, and saturation occurs at ∼20 μM free Ca2+. Small Ca2+ elevations (<0.6 μM) produce discrete waves of depolarization resembling quantum bumps. Stimulating IOCMs with short (20-ms) and long (5-s) light stimuli produces transient light responses (repolarization within ca. 200 ms) in an ICM containing only 10 nM free Ca2+. At 0.44 μM free Ca2+ in the ICM, the microvillar membrane depolarizes by 10–20 mV and responses to 5-s light steps have an initial transient component and a plateau component, similar to responses in intact cells. Generation of the plateau component in IOCMs is suppressed by heparin and cyclopiazonic acid (CPA), agents that block inositol 1,4,5-trisphosphate (Ins(1,4,5)P3)-induced Ca2+ release from and Ca2+ uptake into the endoplasmic reticulum (ER). These results indicate that there is a Ca2+-dependent conductance in the microvillar membrane and that the light-induced Ins(1,4,5)P3- and Ca2+ release-mediated intracellular Ca2+ elevation in leech photoreceptors contributes to the generation of the receptor potential, particularly the plateau component of responses to long steps of light." @default.
• W2092019411 created "2016-06-24" @default.
• W2092019411 creator A5011317424 @default.
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• W2092019411 date "2003-07-01" @default.
• W2092019411 modified "2023-09-28" @default.
• W2092019411 title "Ca2+-dependent and Ca2+ release-dependent excitation in leech photoreceptors: evidence from a novel “inside-out” cell model" @default.
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• W2092019411 doi "https://doi.org/10.1016/s0143-4160(03)00020-4" @default.
• W2092019411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12767891" @default.
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