Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092022164> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2092022164 endingPage "1403" @default.
- W2092022164 startingPage "1400" @default.
- W2092022164 abstract "Exogenously administered human epidermal growth factor (hEGF) shows a marked dose-dependent plasma disposition in rats. In the present study, total plasma clearance (CLtotal) of hEGF was examined from the viewpoint of hepatic blood flow and accessible EGF receptors in a dosing range of hEGF from 30 to 1000 μg/kg. In rats in which down-regulation of EGF receptors caused a reduction in their number (50% below the normal level) (group 1), the CLtotal of hEGF was decreased only at a medium dose (100 μg/kg) compared to those in normal rats. In rats in which hepatic intoxication with carbon tetrachloride caused 50% reduction of both EGF receptor number and hepatic blood flow (group 2), CLtotal was decreased at low and medium hEGF doses. The decrease at a low hEGF dose was proportional to the decrease in the hepatic blood flow. In rats with reduced hepatic blood flow caused by hypothermia (group 3), CLtotal was decreased at all hEGF doses examined, and the decrease at a low hEGF dose (50 μg/kg) was proportional to the hepatic blood flow. The decreases of CLtotal at a medium hEGF dose in groups 1, 2 and 3 were well accounted for by the decrease of hepatic blood flow and/or EGF receptor number in a well-stirred model. Above results indicate that (a) the CLtotal of hEGF at the lower dose is regulated mainly by hepatic blood flow, (b) at the medium dose, both hepatic blood flow and EGF receptor number affect the CLtotal, and, (c) at the higher dose (>500 μg/kg), the contribution of the saturable uptake of hEGF by tissues to CLtotal becomes lower, and CLtotal will be mainly comprised of the extrahepatic clearance." @default.
- W2092022164 created "2016-06-24" @default.
- W2092022164 creator A5016142683 @default.
- W2092022164 creator A5017731860 @default.
- W2092022164 creator A5034574454 @default.
- W2092022164 creator A5039978322 @default.
- W2092022164 creator A5077418138 @default.
- W2092022164 creator A5082148943 @default.
- W2092022164 date "1994-10-01" @default.
- W2092022164 modified "2023-09-24" @default.
- W2092022164 title "Dose-Dependent Plasma Clearance of Human Epidermal Growth Factor in Rats" @default.
- W2092022164 cites W151483314 @default.
- W2092022164 cites W1966671177 @default.
- W2092022164 cites W1966743620 @default.
- W2092022164 cites W1968763311 @default.
- W2092022164 cites W1985033077 @default.
- W2092022164 cites W2004528914 @default.
- W2092022164 cites W2010429702 @default.
- W2092022164 cites W2010577851 @default.
- W2092022164 cites W2064457127 @default.
- W2092022164 cites W2086195758 @default.
- W2092022164 cites W2086271423 @default.
- W2092022164 cites W2091449154 @default.
- W2092022164 cites W2094249810 @default.
- W2092022164 cites W2142365462 @default.
- W2092022164 cites W2178560448 @default.
- W2092022164 doi "https://doi.org/10.1002/jps.2600831007" @default.
- W2092022164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7884658" @default.
- W2092022164 hasPublicationYear "1994" @default.
- W2092022164 type Work @default.
- W2092022164 sameAs 2092022164 @default.
- W2092022164 citedByCount "5" @default.
- W2092022164 crossrefType "journal-article" @default.
- W2092022164 hasAuthorship W2092022164A5016142683 @default.
- W2092022164 hasAuthorship W2092022164A5017731860 @default.
- W2092022164 hasAuthorship W2092022164A5034574454 @default.
- W2092022164 hasAuthorship W2092022164A5039978322 @default.
- W2092022164 hasAuthorship W2092022164A5077418138 @default.
- W2092022164 hasAuthorship W2092022164A5082148943 @default.
- W2092022164 hasConcept C126322002 @default.
- W2092022164 hasConcept C134018914 @default.
- W2092022164 hasConcept C158846371 @default.
- W2092022164 hasConcept C170493617 @default.
- W2092022164 hasConcept C178790620 @default.
- W2092022164 hasConcept C185592680 @default.
- W2092022164 hasConcept C2776362946 @default.
- W2092022164 hasConcept C2777359374 @default.
- W2092022164 hasConcept C71924100 @default.
- W2092022164 hasConcept C86803240 @default.
- W2092022164 hasConceptScore W2092022164C126322002 @default.
- W2092022164 hasConceptScore W2092022164C134018914 @default.
- W2092022164 hasConceptScore W2092022164C158846371 @default.
- W2092022164 hasConceptScore W2092022164C170493617 @default.
- W2092022164 hasConceptScore W2092022164C178790620 @default.
- W2092022164 hasConceptScore W2092022164C185592680 @default.
- W2092022164 hasConceptScore W2092022164C2776362946 @default.
- W2092022164 hasConceptScore W2092022164C2777359374 @default.
- W2092022164 hasConceptScore W2092022164C71924100 @default.
- W2092022164 hasConceptScore W2092022164C86803240 @default.
- W2092022164 hasIssue "10" @default.
- W2092022164 hasLocation W20920221641 @default.
- W2092022164 hasLocation W20920221642 @default.
- W2092022164 hasOpenAccess W2092022164 @default.
- W2092022164 hasPrimaryLocation W20920221641 @default.
- W2092022164 hasRelatedWork W2018368842 @default.
- W2092022164 hasRelatedWork W2021560856 @default.
- W2092022164 hasRelatedWork W2032639135 @default.
- W2092022164 hasRelatedWork W2034583712 @default.
- W2092022164 hasRelatedWork W2040415928 @default.
- W2092022164 hasRelatedWork W2044826694 @default.
- W2092022164 hasRelatedWork W2058424427 @default.
- W2092022164 hasRelatedWork W2063619316 @default.
- W2092022164 hasRelatedWork W2074821979 @default.
- W2092022164 hasRelatedWork W2169225653 @default.
- W2092022164 hasVolume "83" @default.
- W2092022164 isParatext "false" @default.
- W2092022164 isRetracted "false" @default.
- W2092022164 magId "2092022164" @default.
- W2092022164 workType "article" @default.