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- W2092076326 startingPage "55S" @default.
- W2092076326 abstract "Tissue plasminogen activator (tPA) is the only drug approved by the United States Food and Drug Administration for treatment of acute ischemic stroke. Because the drug must be used soon after symptom onset and is associated with intracerebral hemorrhage, tPA remains underutilized. Research has therefore focused on identifying other drugs that can be used concomitantly with tPA to improve the odds of a favorable recovery and to reduce the risk of intracerebral hemorrhage. Minocycline is a broad-spectrum antibiotic that has been found to be a neuroprotective agent in preclinical ischemic stroke models. Minocycline inhibits matrix metalloproteinase-9, a biomarker for intracerebral hemorrhage associated with tPA use. Minocycline is also an antiinflammatory agent and inhibits poly(ADP-ribose) polymerase-1. Minocycline has been safe and well tolerated in clinical trials. Additional safety and efficacy data are needed, and a phase III trial of minocycline with tPA in patients experiencing acute ischemic stroke is planned." @default.
- W2092076326 created "2016-06-24" @default.
- W2092076326 creator A5034973763 @default.
- W2092076326 creator A5049702998 @default.
- W2092076326 date "2010-07-01" @default.
- W2092076326 modified "2023-10-15" @default.
- W2092076326 title "Repurposing an Old Drug to Improve the Use and Safety of Tissue Plasminogen Activator for Acute Ischemic Stroke: Minocycline" @default.
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- W2092076326 doi "https://doi.org/10.1592/phco.30.pt2.55s" @default.
- W2092076326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4730954" @default.
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