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• W2092078286 abstract "A population of fast muscle fibers from aging mice is dependent on external Ca2+ to maintain tetanic force during repeated contractions. We hypothesized that age-related denervation in muscle fibers plays a role in initiating this contractile deficit, and that prevention of denervation by IGF-1 overexpression would prevent external Ca2+-dependent contraction in aging mice. IGF-1 overexpression in skeletal muscle prevents age-related denervation, and prevented external Ca2+-dependent contraction in this work. To determine if the effects of IGF-1 overexpression are on muscle or nerve, aging mice were injected with a tetanus toxin fragment-C (TTC) fusion protein that targets IGF-1 to spinal cord motor neurons. This treatment prevented external Ca2+-dependent contraction. We also show evidence that injections of the IGF-1-TTC fusion protein prevent age-related alterations to the nerve terminals at the neuromuscular junctions. We conclude that the slow age-related denervation of fast muscle fibers underlies dependence on external Ca2+ to maintain tetanic force in a population of muscle fibers from senescent mice." @default.
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• W2092078286 date "2007-04-01" @default.
• W2092078286 modified "2023-10-18" @default.
• W2092078286 title "Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice" @default.
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• W2092078286 doi "https://doi.org/10.1016/j.exger.2006.11.003" @default.
• W2092078286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2063746" @default.
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