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- W2092078490 abstract "Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell growth and differentiation and becomes upregulated by stress, is expressed as AUG-initiated 18 kDa FGF-2 or CUG-initiated 21–34 kDa (hi-FGF-2) isoforms. Animal models have provided strong evidence that FGF-2 is essential for the manifestation of overload- and angiotensin-induced cardiac hypertrophy. Nevertheless, studies to-date have not discriminated between the activities of 18 kDa FGF-2 and hi-FGF-2. Our recent work has pointed to a potent pro-hypertrophic effect of added hi-FGF-2, and a pro-apoptotic effect of sustained intracrine hi-FGF-2 signaling. In the future, it will be important to differentiate between the activities of the different FGF-2 isoforms in the context of adaptive and maladaptive myocardial hypertrophy and heart failure. Based on all available evidence, we propose that while the 18-kDa FGF-2 is a component of an adaptive trophic response, a switch to hi-FGF-2 accumulation would exacerbate hypertrophy and contribute to cell death, thus driving the myocardium towards a maladaptive phenotype." @default.
- W2092078490 created "2016-06-24" @default.
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- W2092078490 date "2004-08-01" @default.
- W2092078490 modified "2023-09-27" @default.
- W2092078490 title "Fibroblast growth factor 2 isoforms and cardiac hypertrophy" @default.
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- W2092078490 doi "https://doi.org/10.1016/j.cardiores.2004.04.024" @default.
- W2092078490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15276471" @default.
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