Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092078694> ?p ?o ?g. }
- W2092078694 endingPage "86" @default.
- W2092078694 startingPage "78" @default.
- W2092078694 abstract "Azithromycin and chloroquine have been shown to exhibit anti-inflammatory activities in a number of cellular systems, but the mechanisms of these activities have still not been clarified unequivocally. Since both drugs are cationic, accumulate in acidic cellular compartments and bind to phospholipids with a consequent increase in lysosomal pH and induce phospholipidosis, we examined the relevance of these common properties to their anti-inflammatory activities. We compared also these effects with effects of concanamycin A, compound which inhibits acidification of lysosomes. All three compounds increased lysosomal pH, accumulation of autophagic vacuoles and ubiquitinated proteins and impaired recycling of TLR4 receptor with consequences in downstream signaling in LPS-stimulated J774A.1 cells. Azithromycin and chloroquine additionally inhibited arachidonic acid release and prostaglandin E2 synthesis. Therefore, impairment of lysosomal functions by azithromycin and chloroquine deregulate TLR4 recycling and signaling and phospholipases activation and lead to anti-inflammatory phenotype in LPS-stimulated J774A.1 cells." @default.
- W2092078694 created "2016-06-24" @default.
- W2092078694 creator A5009500798 @default.
- W2092078694 creator A5050173999 @default.
- W2092078694 creator A5063725425 @default.
- W2092078694 creator A5065473620 @default.
- W2092078694 creator A5076427591 @default.
- W2092078694 date "2012-09-01" @default.
- W2092078694 modified "2023-10-16" @default.
- W2092078694 title "Impairment of lysosomal functions by azithromycin and chloroquine contributes to anti-inflammatory phenotype" @default.
- W2092078694 cites W1527013029 @default.
- W2092078694 cites W1568457937 @default.
- W2092078694 cites W1970937430 @default.
- W2092078694 cites W1973526090 @default.
- W2092078694 cites W1976073973 @default.
- W2092078694 cites W1977047743 @default.
- W2092078694 cites W1980078464 @default.
- W2092078694 cites W1980591213 @default.
- W2092078694 cites W1986642304 @default.
- W2092078694 cites W1993170419 @default.
- W2092078694 cites W1997392516 @default.
- W2092078694 cites W1998906433 @default.
- W2092078694 cites W2000571452 @default.
- W2092078694 cites W2003240557 @default.
- W2092078694 cites W2009600312 @default.
- W2092078694 cites W2010453472 @default.
- W2092078694 cites W2011597257 @default.
- W2092078694 cites W2012254785 @default.
- W2092078694 cites W2026044458 @default.
- W2092078694 cites W2030634755 @default.
- W2092078694 cites W2033608085 @default.
- W2092078694 cites W2035322368 @default.
- W2092078694 cites W2038621186 @default.
- W2092078694 cites W2039343606 @default.
- W2092078694 cites W2045864845 @default.
- W2092078694 cites W2047758711 @default.
- W2092078694 cites W2049528479 @default.
- W2092078694 cites W2055236806 @default.
- W2092078694 cites W2056442594 @default.
- W2092078694 cites W2060727135 @default.
- W2092078694 cites W2062835892 @default.
- W2092078694 cites W2069274385 @default.
- W2092078694 cites W2074680075 @default.
- W2092078694 cites W2077367365 @default.
- W2092078694 cites W2077732560 @default.
- W2092078694 cites W2094895649 @default.
- W2092078694 cites W2096443589 @default.
- W2092078694 cites W2097693747 @default.
- W2092078694 cites W2099769485 @default.
- W2092078694 cites W2105731567 @default.
- W2092078694 cites W2107451523 @default.
- W2092078694 cites W2114046802 @default.
- W2092078694 cites W2125006413 @default.
- W2092078694 cites W2126525190 @default.
- W2092078694 cites W2137617675 @default.
- W2092078694 cites W2139807400 @default.
- W2092078694 cites W2152280976 @default.
- W2092078694 cites W2155682059 @default.
- W2092078694 cites W2156797519 @default.
- W2092078694 cites W2159576879 @default.
- W2092078694 cites W2164191260 @default.
- W2092078694 cites W2167948410 @default.
- W2092078694 cites W2169737738 @default.
- W2092078694 cites W2170466149 @default.
- W2092078694 cites W2222045617 @default.
- W2092078694 cites W69416515 @default.
- W2092078694 doi "https://doi.org/10.1016/j.cellimm.2012.09.007" @default.
- W2092078694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23099154" @default.
- W2092078694 hasPublicationYear "2012" @default.
- W2092078694 type Work @default.
- W2092078694 sameAs 2092078694 @default.
- W2092078694 citedByCount "58" @default.
- W2092078694 countsByYear W20920786942014 @default.
- W2092078694 countsByYear W20920786942015 @default.
- W2092078694 countsByYear W20920786942016 @default.
- W2092078694 countsByYear W20920786942017 @default.
- W2092078694 countsByYear W20920786942018 @default.
- W2092078694 countsByYear W20920786942019 @default.
- W2092078694 countsByYear W20920786942020 @default.
- W2092078694 countsByYear W20920786942021 @default.
- W2092078694 countsByYear W20920786942022 @default.
- W2092078694 countsByYear W20920786942023 @default.
- W2092078694 crossrefType "journal-article" @default.
- W2092078694 hasAuthorship W2092078694A5009500798 @default.
- W2092078694 hasAuthorship W2092078694A5050173999 @default.
- W2092078694 hasAuthorship W2092078694A5063725425 @default.
- W2092078694 hasAuthorship W2092078694A5065473620 @default.
- W2092078694 hasAuthorship W2092078694A5076427591 @default.
- W2092078694 hasConcept C102568950 @default.
- W2092078694 hasConcept C104317684 @default.
- W2092078694 hasConcept C127716648 @default.
- W2092078694 hasConcept C181199279 @default.
- W2092078694 hasConcept C190062978 @default.
- W2092078694 hasConcept C190283241 @default.
- W2092078694 hasConcept C203014093 @default.
- W2092078694 hasConcept C203522944 @default.
- W2092078694 hasConcept C2776070231 @default.
- W2092078694 hasConcept C2776914184 @default.