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• W2092083886 abstract "Objective To review the use and adverse effects of α2-agonists in sheep. Study design Literature review. Material and methods ‘Pubmed’ of the United States National Library of Medicine and ‘Veterinary Science’ of CAB International were searched for references relating sheep to α2-agonists. The bibliographies of retrieved articles were further scrutinized for pertinent references, and relevant articles were selected manually. Results Reports on the use of clonidine, xylazine, detomidine, romifidine, medetomidine and dexmedetomidine, MPV-2426 and ST-91 in sheep were found in the literature. Most of the studies described xylazine followed by medetomidine and clonidine. The literature on detomidine and romifidine in sheep was sparse. Reports included pharmacokinetic studies, evaluation of sedative, analgesic, and anaesthetic techniques with or without cardiovascular effects, and experimental investigations of adverse effects (mainly hypoxaemia) including the mechanisms of pulmonary oedema and impaired oxygenation after α2-agonist administration. Conclusions A2-agonists are potent and effective analgesics in sheep. In combination with ketamine, they are frequently used for the induction and maintenance of anaesthesia, in this case analgesia is satisfactory. The degree of hypoxaemia which occurs with all commercially available α2-agonists is highly variable and depends on individual or breed-related factors; the most severe reactions occur after intravenous (IV) injection and during general anaesthesia. Clinical relevance Subclinical respiratory disease is common in sheep. Rapid IV injection of α2-agonists without supplementary oxygen should be avoided whenever hypoxaemia may be critical." @default.
• W2092083886 created "2016-06-24" @default.
• W2092083886 creator A5027155018 @default.
• W2092083886 date "2006-03-01" @default.
• W2092083886 modified "2023-10-11" @default.
• W2092083886 title "A2-agonists in sheep: a review" @default.
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• W2092083886 doi "https://doi.org/10.1111/j.1467-2995.2005.00243.x" @default.
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