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- W2092097319 abstract "Unscheduled DNA synthesis has been measured in human fibroblasts under conditions of reduced rates of conversion of NAD to poly)ADP-ribose). Cells heterozygous for the xeroderma pigmentosum genotype showed normal rates of UV induced unscheduled DNA synthesis under conditions in which the rate of poly(ADP-ribose) synthesis was one-half the rate of normal cells. The addition of theophylline, a potent inhibitor of poly(ADP-ribose) polymerase, to the culture medium of normal cells blocked over 90% of the conversion of NAD to poly(ADP-ribose) following treatment with UV or N-methyl-N'-nitro-N-nitro-soguanidine but did not affect the rate of unscheduled DNA synthesis." @default.
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- W2092097319 date "1981-01-01" @default.
- W2092097319 modified "2023-09-27" @default.
- W2092097319 title "Unscheduled synthesis of DNA and poly(ADP-ribose) in human fibroblasts following DNA damage" @default.
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- W2092097319 doi "https://doi.org/10.1002/jsscb.380170110" @default.
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