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- W2092100048 abstract "The phylogeny of classical swine fever virus (CSFV), the causative agent of classical swine fever (CSF), has been investigated extensively. However, no evolutionary research has been performed using the whole CSFV genome. In this study, we used 37 published genome sequences to investigate the time-calibrated phylogenomics of CSFV. In phylogenomic trees based on Bayesian inference (BI) and Maximum likelihood (ML), the 37 isolates were categorized into five genetic types (1.1, 1.2, 2.1, 2.3, and 3.4). Subgenotype 1.1 is divided into 3 groups and 1 unclassified isolate, 2.1 into 4 groups, 2.3 into 2 groups and 1 unclassified isolate, and subgenotype 1.2 and 3.4 consisted of one isolate each. We did not observe an apparent temporal or geographical relationship between isolates. Of the 14 genomic regions, NS4B showed the most powerful phylogenetic signal. Results of this evolutionary study using Bayesian coalescent approach indicate that CSFV has evolved at a rate of 13×.010-4 substitutions per site per year. The most recent common ancestor of CSFV appeared 2770.2 years ago, which was about 8000 years after pig domestication. The effective population size of CSFV underwent a slow increase until the 1950s, after which it has remained constant." @default.
- W2092100048 created "2016-06-24" @default.
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- W2092100048 date "2015-03-27" @default.
- W2092100048 modified "2023-09-26" @default.
- W2092100048 title "Time-Calibrated Phylogenomics of the Classical Swine Fever Viruses: Genome-Wide Bayesian Coalescent Approach" @default.
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- W2092100048 doi "https://doi.org/10.1371/journal.pone.0121578" @default.
- W2092100048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4376735" @default.
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