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• W2092104080 abstract "The anti-CD20 monoclonal antibody rituximab has shown activity in approximately one third of patients with Waldenström's Macroglobulinemia (WM). Because this agents is nonmyelosuppressive, several studies have assessed its combination with chemotherapeutic agents such as fludarabine, cladribine, cyclophosphamide, and doxorubicin. These regimens induce at least partial response in > 70% of previously untreated patients. Recent data suggest that prolonged exposure to nucleoside-containing regimens should be avoided because of concerns of myelodysplasia and disease transformation. Rituximab has also been combined with thalidomide, which is an active and nonmyelosuppressive regimen. The rituximab-based combination represents today the most commonly used primary treatment for WM." @default.
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• W2092104080 date "2009-03-01" @default.
• W2092104080 modified "2023-10-16" @default.
• W2092104080 title "Rituximab-Based Treatments in Waldenström's Macroglobulinemia" @default.
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• W2092104080 doi "https://doi.org/10.3816/clm.2009.n.015" @default.
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