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• W2092104384 abstract "The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in many sporadic colorectal tumors. The carboxyl-terminal S/TXV motif of the APC gene product interacts with the PDZ domain of hDLG, the human homolog of the Drosophila lethal (1) discs larige-1 (dlg) tumor suppressor. In the present study, we found that overexpression of hDLG suppresses cell proliferation by blocking cell cycle progression from the G0/G1 to S phase. This inhibition of cell cycle progression was abolished when the PDZ, SH3 or guanylate kinase-like domain of hDLG was mutated. Moreover, overexpression of these mutant hDLGs partially interfered with the cell cycle blocking activity of APC. Consistent with this result, mutant APC lacking the S/TXV motif exhibited weaker cell cycle blocking activity than the intact APC. These results suggest that APC-hDLG complex formation plays an important role in transducing the APC cell cycle blocking signal." @default.
• W2092104384 created "2016-06-24" @default.
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• W2092104384 date "2000-01-20" @default.
• W2092104384 modified "2023-10-11" @default.
• W2092104384 title "The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase" @default.
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• W2092104384 doi "https://doi.org/10.1038/sj.onc.1203309" @default.
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