FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092104690> ?p ?o ?g. }

• W2092104690 abstract "Hepatoblastoma is the most common primary hepatic malignancy of childhood, frequently presenting as advanced disease. Vascular endothelial growth factor (VEGF) is an endothelial mitogen and survival factor critical to growth and angiogenesis in many human cancers. Inhibition of VEGF effectively suppresses tumorigenesis in multiple experimental models. The authors hypothesized that anti-VEGF antibody would alter vascular architecture and impede tumor growth in experimental hepatoblastoma.The Institutional Animal Care and Use Committee of Columbia University approved all protocols. Xenografts were established in athymic mice by intrarenal injection of cultured human hepatoblastoma cells. Anti-VEGF antibody (100 microg/dose) or vehicle was administered intraperitoneally 2 times per week for 5 weeks. At week 6, 10 control/treated mice were killed and remaining animals maintained without treatment until week 8. Tumor weights were compared by Kruskal-Wallis analysis, and vascular alterations ascertained by fluorescein angiography and specific immunostaining.Anti-VEGF antibody significantly inhibited tumor growth at 6 weeks (1.85 g +/- 0.60 control, 0.05 +/- 0.03 antibody, P <.0003). In comparison with controls, treated xenografts showed decreased vascularity and dilated surviving vessels with prominent vascular smooth muscle elements.Specific anti-VEGF therapy inhibits neoangiogenesis and significantly suppresses tumor growth in experimental hepatoblastoma. Surviving vasculature displays dilation and increased vascular smooth muscle. Anti-VEGF agents may represent new therapeutic alternatives for children with advanced disease." @default.
• W2092104690 created "2016-06-24" @default.
• W2092104690 creator A5008246426 @default.
• W2092104690 creator A5016121478 @default.
• W2092104690 creator A5021328371 @default.
• W2092104690 creator A5031841410 @default.
• W2092104690 creator A5040794176 @default.
• W2092104690 creator A5066479735 @default.
• W2092104690 creator A5066741788 @default.
• W2092104690 creator A5067877209 @default.
• W2092104690 creator A5078860285 @default.
• W2092104690 creator A5079525182 @default.
• W2092104690 creator A5089824141 @default.
• W2092104690 date "2003-03-01" @default.
• W2092104690 modified "2023-09-26" @default.
• W2092104690 title "Anti-VEGF antibody in experimental hepatoblastoma: Suppression of tumor growth and altered angiogenesis" @default.
• W2092104690 cites W1804903119 @default.
• W2092104690 cites W1928144700 @default.
• W2092104690 cites W1969328947 @default.
• W2092104690 cites W1976729788 @default.
• W2092104690 cites W1983763042 @default.
• W2092104690 cites W1988307856 @default.
• W2092104690 cites W1999544371 @default.
• W2092104690 cites W2002049222 @default.
• W2092104690 cites W2049972026 @default.
• W2092104690 cites W2054822632 @default.
• W2092104690 cites W2064726235 @default.
• W2092104690 cites W2081455603 @default.
• W2092104690 cites W2086780755 @default.
• W2092104690 cites W2087523741 @default.
• W2092104690 cites W2090401954 @default.
• W2092104690 cites W2094794021 @default.
• W2092104690 cites W2113768167 @default.
• W2092104690 cites W2135984915 @default.
• W2092104690 cites W2138843392 @default.
• W2092104690 cites W2158743409 @default.
• W2092104690 doi "https://doi.org/10.1053/jpsu.2003.50099" @default.
• W2092104690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12632340" @default.
• W2092104690 hasPublicationYear "2003" @default.
• W2092104690 type Work @default.
• W2092104690 sameAs 2092104690 @default.
• W2092104690 citedByCount "28" @default.
• W2092104690 countsByYear W20921046902012 @default.
• W2092104690 countsByYear W20921046902013 @default.
• W2092104690 countsByYear W20921046902014 @default.
• W2092104690 countsByYear W20921046902016 @default.
• W2092104690 countsByYear W20921046902019 @default.
• W2092104690 countsByYear W20921046902021 @default.
• W2092104690 crossrefType "journal-article" @default.
• W2092104690 hasAuthorship W2092104690A5008246426 @default.
• W2092104690 hasAuthorship W2092104690A5016121478 @default.
• W2092104690 hasAuthorship W2092104690A5021328371 @default.
• W2092104690 hasAuthorship W2092104690A5031841410 @default.
• W2092104690 hasAuthorship W2092104690A5040794176 @default.
• W2092104690 hasAuthorship W2092104690A5066479735 @default.
• W2092104690 hasAuthorship W2092104690A5066741788 @default.
• W2092104690 hasAuthorship W2092104690A5067877209 @default.
• W2092104690 hasAuthorship W2092104690A5078860285 @default.
• W2092104690 hasAuthorship W2092104690A5079525182 @default.
• W2092104690 hasAuthorship W2092104690A5089824141 @default.
• W2092104690 hasConcept C126322002 @default.
• W2092104690 hasConcept C134018914 @default.
• W2092104690 hasConcept C142724271 @default.
• W2092104690 hasConcept C159654299 @default.
• W2092104690 hasConcept C167734588 @default.
• W2092104690 hasConcept C203014093 @default.
• W2092104690 hasConcept C204232928 @default.
• W2092104690 hasConcept C2776304256 @default.
• W2092104690 hasConcept C2777025900 @default.
• W2092104690 hasConcept C2779399171 @default.
• W2092104690 hasConcept C2780394083 @default.
• W2092104690 hasConcept C4224716 @default.
• W2092104690 hasConcept C502942594 @default.
• W2092104690 hasConcept C71924100 @default.
• W2092104690 hasConceptScore W2092104690C126322002 @default.
• W2092104690 hasConceptScore W2092104690C134018914 @default.
• W2092104690 hasConceptScore W2092104690C142724271 @default.
• W2092104690 hasConceptScore W2092104690C159654299 @default.
• W2092104690 hasConceptScore W2092104690C167734588 @default.
• W2092104690 hasConceptScore W2092104690C203014093 @default.
• W2092104690 hasConceptScore W2092104690C204232928 @default.
• W2092104690 hasConceptScore W2092104690C2776304256 @default.
• W2092104690 hasConceptScore W2092104690C2777025900 @default.
• W2092104690 hasConceptScore W2092104690C2779399171 @default.
• W2092104690 hasConceptScore W2092104690C2780394083 @default.
• W2092104690 hasConceptScore W2092104690C4224716 @default.
• W2092104690 hasConceptScore W2092104690C502942594 @default.
• W2092104690 hasConceptScore W2092104690C71924100 @default.
• W2092104690 hasLocation W20921046901 @default.
• W2092104690 hasLocation W20921046902 @default.
• W2092104690 hasOpenAccess W2092104690 @default.
• W2092104690 hasPrimaryLocation W20921046901 @default.
• W2092104690 hasRelatedWork W1987662957 @default.
• W2092104690 hasRelatedWork W1998292671 @default.
• W2092104690 hasRelatedWork W2009872653 @default.
• W2092104690 hasRelatedWork W2074042077 @default.
• W2092104690 hasRelatedWork W2131609900 @default.
• W2092104690 hasRelatedWork W2160926771 @default.
• W2092104690 hasRelatedWork W2388551474 @default.
• W2092104690 hasRelatedWork W2402143932 @default.

• next