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- W2092104902 abstract "Patients with advanced liver disease require aggressivemanagement of the protein-calorie malnutrition associ-ated with the diagnosis. However, toxicity and toler-ance thresholds for nutritional intervention are very low.These thresholds are defined largely by the failing liver’smetabolic derangements. Attention needs to be givento ensuring optimal amino acid nutriture without pre-cipitating hepatic encephalopathy. Adequate calorieprovision is necessary for maximal use of the adminis-tered protein. Micronutrient disposition in the chronicliver disease patient is compromised for metals, neces-sitating monitoring of iron status and possibly that ofcopper. Vitamin A status also may need to be deter-mined, especially in light of its implicated hepatotoxinstatus with large cumulative doses. The iatrogenic liverdisease induced by long-term total parenteral nutritionis relatively rare but frequently amenable to refinementof the regimen, in addition to intervention with carnitinesupplementation in select cases. The above insights areimportant in tailoring the nutritional plan and will leadto better patient outcomes in concert with medical in-tervention. Nutr Clin Care. 2001;4:87–93" @default.
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- W2092104902 date "2001-03-01" @default.
- W2092104902 modified "2023-09-27" @default.
- W2092104902 title "Nutritional Issues in the Management of Advanced Liver Disease" @default.
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- W2092104902 doi "https://doi.org/10.1046/j.1523-5408.2001.00120.x" @default.
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