FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092108597> ?p ?o ?g. }

• W2092108597 endingPage "688" @default.
• W2092108597 startingPage "679" @default.
• W2092108597 abstract "Stavudine is a nucleoside analogue used for the treatment of HIV-1 infection, as part of highly active antiretroviral treatment. In developing countries, stavudine is used widely, owing to low cost and inclusion in generic fixed-dose combinations. In developed countries, stavudine is now rarely used, although it is highly effective. This is because newer drugs show lower rates of mitochondrial toxicities, such as lipoatrophy, peripheral neuropathy and lactic acidosis. In the development of stavudine, there was evidence that a dosage of 20-30 mg b.i.d. was effective, but the 40-mg b.i.d. dose gained regulatory approval. This review analyses the clinical trials conducted before and after the regulatory approval of stavudine, and shows that the dose of 30 mg b.i.d. has equivalent antiviral efficacy (given the caveats of meta-analysis), with some evidence of lower rates of peripheral neuropathy and lipoatrophy. With limited resources for HIV-1 treatment in developing countries, and only 25% of eligible patients receiving highly active antiretroviral treatment, low-cost treatment options such as stavudine still need to be pursued, if safety can be improved by dose optimisation." @default.
• W2092108597 created "2016-06-24" @default.
• W2092108597 creator A5001003748 @default.
• W2092108597 creator A5009751300 @default.
• W2092108597 creator A5017386021 @default.
• W2092108597 creator A5033023982 @default.
• W2092108597 creator A5053903761 @default.
• W2092108597 creator A5060462160 @default.
• W2092108597 creator A5063972076 @default.
• W2092108597 creator A5064111819 @default.
• W2092108597 creator A5067689210 @default.
• W2092108597 date "2007-03-22" @default.
• W2092108597 modified "2023-09-30" @default.
• W2092108597 title "Systematic review of clinical trials evaluating low doses of stavudine as part of antiretroviral treatment" @default.
• W2092108597 cites W1964748194 @default.
• W2092108597 cites W1979092952 @default.
• W2092108597 cites W1997900349 @default.
• W2092108597 cites W2004967417 @default.
• W2092108597 cites W2005873387 @default.
• W2092108597 cites W2025689551 @default.
• W2092108597 cites W2033995953 @default.
• W2092108597 cites W2043888412 @default.
• W2092108597 cites W2044446348 @default.
• W2092108597 cites W2052991207 @default.
• W2092108597 cites W2054306124 @default.
• W2092108597 cites W2056779298 @default.
• W2092108597 cites W2065293221 @default.
• W2092108597 cites W2076562284 @default.
• W2092108597 cites W2122280827 @default.
• W2092108597 cites W2124801504 @default.
• W2092108597 cites W2127970905 @default.
• W2092108597 cites W2133166320 @default.
• W2092108597 cites W2141776019 @default.
• W2092108597 cites W2151052918 @default.
• W2092108597 cites W2166133686 @default.
• W2092108597 cites W2323785681 @default.
• W2092108597 cites W3028262166 @default.
• W2092108597 doi "https://doi.org/10.1517/14656566.8.5.679" @default.
• W2092108597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17376022" @default.
• W2092108597 hasPublicationYear "2007" @default.
• W2092108597 type Work @default.
• W2092108597 sameAs 2092108597 @default.
• W2092108597 citedByCount "78" @default.
• W2092108597 countsByYear W20921085972012 @default.
• W2092108597 countsByYear W20921085972013 @default.
• W2092108597 countsByYear W20921085972014 @default.
• W2092108597 countsByYear W20921085972015 @default.
• W2092108597 countsByYear W20921085972017 @default.
• W2092108597 countsByYear W20921085972018 @default.
• W2092108597 countsByYear W20921085972019 @default.
• W2092108597 crossrefType "journal-article" @default.
• W2092108597 hasAuthorship W2092108597A5001003748 @default.
• W2092108597 hasAuthorship W2092108597A5009751300 @default.
• W2092108597 hasAuthorship W2092108597A5017386021 @default.
• W2092108597 hasAuthorship W2092108597A5033023982 @default.
• W2092108597 hasAuthorship W2092108597A5053903761 @default.
• W2092108597 hasAuthorship W2092108597A5060462160 @default.
• W2092108597 hasAuthorship W2092108597A5063972076 @default.
• W2092108597 hasAuthorship W2092108597A5064111819 @default.
• W2092108597 hasAuthorship W2092108597A5067689210 @default.
• W2092108597 hasConcept C126322002 @default.
• W2092108597 hasConcept C142462285 @default.
• W2092108597 hasConcept C177713679 @default.
• W2092108597 hasConcept C203014093 @default.
• W2092108597 hasConcept C2777447569 @default.
• W2092108597 hasConcept C2779546735 @default.
• W2092108597 hasConcept C2779889181 @default.
• W2092108597 hasConcept C2993143319 @default.
• W2092108597 hasConcept C3013748606 @default.
• W2092108597 hasConcept C535046627 @default.
• W2092108597 hasConcept C71924100 @default.
• W2092108597 hasConcept C98274493 @default.
• W2092108597 hasConceptScore W2092108597C126322002 @default.
• W2092108597 hasConceptScore W2092108597C142462285 @default.
• W2092108597 hasConceptScore W2092108597C177713679 @default.
• W2092108597 hasConceptScore W2092108597C203014093 @default.
• W2092108597 hasConceptScore W2092108597C2777447569 @default.
• W2092108597 hasConceptScore W2092108597C2779546735 @default.
• W2092108597 hasConceptScore W2092108597C2779889181 @default.
• W2092108597 hasConceptScore W2092108597C2993143319 @default.
• W2092108597 hasConceptScore W2092108597C3013748606 @default.
• W2092108597 hasConceptScore W2092108597C535046627 @default.
• W2092108597 hasConceptScore W2092108597C71924100 @default.
• W2092108597 hasConceptScore W2092108597C98274493 @default.
• W2092108597 hasIssue "5" @default.
• W2092108597 hasLocation W20921085971 @default.
• W2092108597 hasLocation W20921085972 @default.
• W2092108597 hasOpenAccess W2092108597 @default.
• W2092108597 hasPrimaryLocation W20921085971 @default.
• W2092108597 hasRelatedWork W2008749424 @default.
• W2092108597 hasRelatedWork W2016405286 @default.
• W2092108597 hasRelatedWork W2016765364 @default.
• W2092108597 hasRelatedWork W2072513579 @default.
• W2092108597 hasRelatedWork W2101615600 @default.
• W2092108597 hasRelatedWork W2110484800 @default.
• W2092108597 hasRelatedWork W2154233287 @default.
• W2092108597 hasRelatedWork W2316412239 @default.
• W2092108597 hasRelatedWork W2317670225 @default.

• next