FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092110406> ?p ?o ?g. }

• W2092110406 endingPage "1152" @default.
• W2092110406 startingPage "1143" @default.
• W2092110406 abstract "Campylobacter fetus is a Gram negative bacterium recognized for its virulence in animals and humans. This bacterium possesses a paracrystalline array of high molecular weight proteins known as surface-layer proteins covering its cell surface. A mathematical model has been made of the outer membrane of this bacterium, both with its surface-layer proteins (S +) and without (S −). Monte Carlo computer simulation was used to understand the stability of the surface-layer protein structure as a function of ionic concentration. The interactions of an electrically-charged antimicrobial agent, the cationic antimicrobial peptide protamine, with surface-layer proteins and with the lipopolysaccharides of the outer membrane were modeled and analyzed. We found that (1) divalent ions stabilize the surface-layer protein array by reducing the fluctuations perpendicular and parallel to the membrane plane thereby promoting adhesion to the LPS region. This was achieved via (2) divalent ions bridging the negatively-charged LPS Core. The effect of this bridging is to bring individual Core regions closer together so that the O-antigens can (3) increase their attractive van der Waals interactions and “collapse” to form a surface with reduced perpendicular fluctuations. These findings provide support for the proposal of Yang et al. [1]. (4) No evidence for a significant increase in Ca2 + concentration in the region of the surface-layer protein subunits was observed in S + simulations compared to S − simulations. (5) We predicted the trends of protamine MIC tests performed on C. fetus and these were in good agreement with our experimental results." @default.
• W2092110406 created "2016-06-24" @default.
• W2092110406 creator A5041853284 @default.
• W2092110406 creator A5069425440 @default.
• W2092110406 creator A5078017301 @default.
• W2092110406 creator A5088569361 @default.
• W2092110406 date "2013-03-01" @default.
• W2092110406 modified "2023-10-18" @default.
• W2092110406 title "Modeling the surface of campylobacter fetus: Protein surface layer stability and resistance to cationic antimicrobial peptides" @default.
• W2092110406 cites W1503700499 @default.
• W2092110406 cites W1533022293 @default.
• W2092110406 cites W1631741342 @default.
• W2092110406 cites W1679863787 @default.
• W2092110406 cites W1762697277 @default.
• W2092110406 cites W1832152993 @default.
• W2092110406 cites W1864768268 @default.
• W2092110406 cites W1900043610 @default.
• W2092110406 cites W1924439116 @default.
• W2092110406 cites W1933722356 @default.
• W2092110406 cites W1963863472 @default.
• W2092110406 cites W1964717752 @default.
• W2092110406 cites W1981021420 @default.
• W2092110406 cites W1986106933 @default.
• W2092110406 cites W1994261266 @default.
• W2092110406 cites W2006748749 @default.
• W2092110406 cites W2011379305 @default.
• W2092110406 cites W2026782692 @default.
• W2092110406 cites W2030942238 @default.
• W2092110406 cites W2032729921 @default.
• W2092110406 cites W2035454388 @default.
• W2092110406 cites W2035750150 @default.
• W2092110406 cites W2040902755 @default.
• W2092110406 cites W2042055329 @default.
• W2092110406 cites W2043258776 @default.
• W2092110406 cites W2047945065 @default.
• W2092110406 cites W2052058305 @default.
• W2092110406 cites W2052767840 @default.
• W2092110406 cites W2060259273 @default.
• W2092110406 cites W2082688835 @default.
• W2092110406 cites W2088708755 @default.
• W2092110406 cites W2099667692 @default.
• W2092110406 cites W2110013160 @default.
• W2092110406 cites W2111394390 @default.
• W2092110406 cites W2120312036 @default.
• W2092110406 cites W2127214408 @default.
• W2092110406 cites W2130476437 @default.
• W2092110406 cites W2139231693 @default.
• W2092110406 cites W2158274729 @default.
• W2092110406 cites W2159529419 @default.
• W2092110406 cites W3101508961 @default.
• W2092110406 cites W4232105388 @default.
• W2092110406 cites W4244949868 @default.
• W2092110406 cites W998175253 @default.
• W2092110406 doi "https://doi.org/10.1016/j.bbamem.2012.10.025" @default.
• W2092110406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23122778" @default.
• W2092110406 hasPublicationYear "2013" @default.
• W2092110406 type Work @default.
• W2092110406 sameAs 2092110406 @default.
• W2092110406 citedByCount "2" @default.
• W2092110406 countsByYear W20921104062014 @default.
• W2092110406 countsByYear W20921104062021 @default.
• W2092110406 crossrefType "journal-article" @default.
• W2092110406 hasAuthorship W2092110406A5041853284 @default.
• W2092110406 hasAuthorship W2092110406A5069425440 @default.
• W2092110406 hasAuthorship W2092110406A5078017301 @default.
• W2092110406 hasAuthorship W2092110406A5088569361 @default.
• W2092110406 hasBestOaLocation W20921104061 @default.
• W2092110406 hasConcept C12554922 @default.
• W2092110406 hasConcept C159467904 @default.
• W2092110406 hasConcept C185592680 @default.
• W2092110406 hasConcept C2777557582 @default.
• W2092110406 hasConcept C2777595706 @default.
• W2092110406 hasConcept C2779910956 @default.
• W2092110406 hasConcept C2780835560 @default.
• W2092110406 hasConcept C41625074 @default.
• W2092110406 hasConcept C523546767 @default.
• W2092110406 hasConcept C54355233 @default.
• W2092110406 hasConcept C55493867 @default.
• W2092110406 hasConcept C8010536 @default.
• W2092110406 hasConcept C86803240 @default.
• W2092110406 hasConceptScore W2092110406C12554922 @default.
• W2092110406 hasConceptScore W2092110406C159467904 @default.
• W2092110406 hasConceptScore W2092110406C185592680 @default.
• W2092110406 hasConceptScore W2092110406C2777557582 @default.
• W2092110406 hasConceptScore W2092110406C2777595706 @default.
• W2092110406 hasConceptScore W2092110406C2779910956 @default.
• W2092110406 hasConceptScore W2092110406C2780835560 @default.
• W2092110406 hasConceptScore W2092110406C41625074 @default.
• W2092110406 hasConceptScore W2092110406C523546767 @default.
• W2092110406 hasConceptScore W2092110406C54355233 @default.
• W2092110406 hasConceptScore W2092110406C55493867 @default.
• W2092110406 hasConceptScore W2092110406C8010536 @default.
• W2092110406 hasConceptScore W2092110406C86803240 @default.
• W2092110406 hasIssue "3" @default.
• W2092110406 hasLocation W20921104061 @default.
• W2092110406 hasLocation W20921104062 @default.
• W2092110406 hasOpenAccess W2092110406 @default.
• W2092110406 hasPrimaryLocation W20921104061 @default.

• next