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- W2092113822 abstract "Lipids normally found in plasma do not appreciably effect formation of thrombin from prothrombin. This was demonstrated by finding that normal and lipid-poor plasma clotted almost with equal rapidity when calcium ions and purified autoprothrombin C (Factor Xa) were added. Lipid-poor plasma and normal plasma served equally well to test the lipid requirements of autoprothrombin C in thrombin formation. Of the purified phospholipids tested, phosphatidylserine and phosphatidylinositol were the most effective. Whole brain thromboplastin or its lipid portion alone or platelet factor 3 preparations also accelerated thrombin formation. Phosphatidylethanolamine and choline were virtually ineffective. The lipid requirements for autoprothrombin C formation are different from those required by autoprothrombin C to generate thrombin from prothrombin." @default.
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- W2092113822 date "1974-03-01" @default.
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- W2092113822 title "Phospholipid requirements in thrombin formation" @default.
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- W2092113822 doi "https://doi.org/10.1016/0049-3848(74)90079-6" @default.
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