FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092114401> ?p ?o ?g. }

• W2092114401 endingPage "181" @default.
• W2092114401 startingPage "173" @default.
• W2092114401 abstract "A natural deficiency of hepatic lipase in rabbits has been exploited to gain insights into the physiological role of this enzyme in the metabolism of plasma lipoproteins. A comparison of human and rabbit lipoproteins revealed obvious species differences in both low-density lipoproteins (LDL) and high-density lipoproteins (HDL), with the rabbit lipoproteins being relatively enlarged, enriched in triacylglycerol and depleted of cholesteryl ester. To test whether these differences related to the low level of hepatic lipase in rabbits, whole plasma or the total lipoprotein fraction from rabbits was either kept at 4 degrees C or incubated at 37 degrees C for 7 h in (i) the absence of lipase, (ii) the presence of hepatic lipase and (iii) the presence of lipoprotein lipase. Following incubation, the lipoproteins were recovered and subjected to gel permeation chromatography to determine the distribution of lipoprotein components across the entire lipoprotein spectrum. An aliquot of the lipoproteins was subjected also to gradient gel electrophoresis to determine the particle size distribution of the LDL and HDL. Both hepatic lipase and lipoprotein lipase hydrolysed lipoprotein triacylglycerol and to a much lesser extent, also phospholipid. There were, however, obvious differences between the enzymes in terms of substrate specificity. In incubations containing hepatic lipase, there was a preferential hydrolysis of HDL triacylglycerol and a lesser hydrolysis of VLDL triacylglycerol. By contrast, lipoprotein lipase acted primarily on VLDL triacylglycerol. When more enzyme was added, both lipases also acted on LDL triacylglycerol, but in no experiment did lipoprotein lipase hydrolyse the triacylglycerol in HDL. Coincident with the hepatic lipase-induced hydrolysis of LDL and HDL triacylglycerol, there were marked reductions in the particle size of both lipoprotein fractions, which were now comparable to those of human LDL and HDL3, respectively." @default.
• W2092114401 created "2016-06-24" @default.
• W2092114401 creator A5013655811 @default.
• W2092114401 creator A5041221542 @default.
• W2092114401 creator A5043534256 @default.
• W2092114401 creator A5073952748 @default.
• W2092114401 date "1989-04-01" @default.
• W2092114401 modified "2023-10-16" @default.
• W2092114401 title "The rabbit as an animal model of hepatic lipase deficiency" @default.
• W2092114401 cites W1499909373 @default.
• W2092114401 cites W1512559452 @default.
• W2092114401 cites W1520348962 @default.
• W2092114401 cites W1526188349 @default.
• W2092114401 cites W1582963798 @default.
• W2092114401 cites W1584290267 @default.
• W2092114401 cites W1584783488 @default.
• W2092114401 cites W1775749144 @default.
• W2092114401 cites W1877509451 @default.
• W2092114401 cites W1964513423 @default.
• W2092114401 cites W1967041734 @default.
• W2092114401 cites W1992111419 @default.
• W2092114401 cites W1993060489 @default.
• W2092114401 cites W1996567434 @default.
• W2092114401 cites W1998310851 @default.
• W2092114401 cites W2001752924 @default.
• W2092114401 cites W2006571152 @default.
• W2092114401 cites W2052578635 @default.
• W2092114401 cites W2054839341 @default.
• W2092114401 cites W2057600299 @default.
• W2092114401 cites W2060546043 @default.
• W2092114401 cites W2063725259 @default.
• W2092114401 cites W2066200110 @default.
• W2092114401 cites W2073336522 @default.
• W2092114401 cites W2074655408 @default.
• W2092114401 cites W2092903259 @default.
• W2092114401 cites W2100837269 @default.
• W2092114401 cites W2125858982 @default.
• W2092114401 cites W2136215037 @default.
• W2092114401 cites W2146290330 @default.
• W2092114401 cites W2161721693 @default.
• W2092114401 cites W2173345687 @default.
• W2092114401 cites W2187445621 @default.
• W2092114401 cites W2208699902 @default.
• W2092114401 cites W2324176011 @default.
• W2092114401 cites W2412671666 @default.
• W2092114401 doi "https://doi.org/10.1016/0005-2760(89)90284-1" @default.
• W2092114401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2930766" @default.
• W2092114401 hasPublicationYear "1989" @default.
• W2092114401 type Work @default.
• W2092114401 sameAs 2092114401 @default.
• W2092114401 citedByCount "63" @default.
• W2092114401 countsByYear W20921144012012 @default.
• W2092114401 countsByYear W20921144012013 @default.
• W2092114401 countsByYear W20921144012015 @default.
• W2092114401 countsByYear W20921144012018 @default.
• W2092114401 countsByYear W20921144012020 @default.
• W2092114401 countsByYear W20921144012021 @default.
• W2092114401 countsByYear W20921144012022 @default.
• W2092114401 crossrefType "journal-article" @default.
• W2092114401 hasAuthorship W2092114401A5013655811 @default.
• W2092114401 hasAuthorship W2092114401A5041221542 @default.
• W2092114401 hasAuthorship W2092114401A5043534256 @default.
• W2092114401 hasAuthorship W2092114401A5073952748 @default.
• W2092114401 hasConcept C126322002 @default.
• W2092114401 hasConcept C134018914 @default.
• W2092114401 hasConcept C181199279 @default.
• W2092114401 hasConcept C185592680 @default.
• W2092114401 hasConcept C2776448209 @default.
• W2092114401 hasConcept C2778163477 @default.
• W2092114401 hasConcept C2778918659 @default.
• W2092114401 hasConcept C2779697368 @default.
• W2092114401 hasConcept C2780072125 @default.
• W2092114401 hasConcept C2780213950 @default.
• W2092114401 hasConcept C2780786110 @default.
• W2092114401 hasConcept C41625074 @default.
• W2092114401 hasConcept C55493867 @default.
• W2092114401 hasConcept C71924100 @default.
• W2092114401 hasConcept C8004288 @default.
• W2092114401 hasConcept C8243546 @default.
• W2092114401 hasConcept C86803240 @default.
• W2092114401 hasConcept C94879076 @default.
• W2092114401 hasConceptScore W2092114401C126322002 @default.
• W2092114401 hasConceptScore W2092114401C134018914 @default.
• W2092114401 hasConceptScore W2092114401C181199279 @default.
• W2092114401 hasConceptScore W2092114401C185592680 @default.
• W2092114401 hasConceptScore W2092114401C2776448209 @default.
• W2092114401 hasConceptScore W2092114401C2778163477 @default.
• W2092114401 hasConceptScore W2092114401C2778918659 @default.
• W2092114401 hasConceptScore W2092114401C2779697368 @default.
• W2092114401 hasConceptScore W2092114401C2780072125 @default.
• W2092114401 hasConceptScore W2092114401C2780213950 @default.
• W2092114401 hasConceptScore W2092114401C2780786110 @default.
• W2092114401 hasConceptScore W2092114401C41625074 @default.
• W2092114401 hasConceptScore W2092114401C55493867 @default.
• W2092114401 hasConceptScore W2092114401C71924100 @default.
• W2092114401 hasConceptScore W2092114401C8004288 @default.
• W2092114401 hasConceptScore W2092114401C8243546 @default.
• W2092114401 hasConceptScore W2092114401C86803240 @default.

• next