FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092114519> ?p ?o ?g. }

• W2092114519 abstract "The antineoplastic alkylating agent, cyclophosphamide (CPA) is known to impair normal female reproductive function. We have examined the time- and dose-dependent effects of CPA on the ovary, specifically, its impact on follicle numbers, ovarian morphometrics, and estradiol (E2) production. Female C57BL/6N mice were treated ip with CPA in normal saline at doses of 0, 75, 200, or 500 mg/kg. Ovaries were removed 1 to 14 days following treatment and serial sections were prepared. Differential follicle counts revealed that primordial follicles were most sensitive to CPA (ED50 = 122 mg/kg), followed by antral and growing follicles. Primordial follicles were affected by all doses of CPA and were completely destroyed by 3 days in the 500 mg/kg dose group. The greatest reduction in antral follicles was to 49% and 7% of controls by CPA doses of 200 and 500 mg/kg, respectively. Plasma E2 concentrations correlated best with antral follicle numbers (r2 = 0.94) and antral follicle volume (r2 = 0.88). Growing follicles were least sensitive to CPA and only decreased at 7 and 14 days. Although atretic changes were observed in growing follicles after treatment with CPA, these follicles recovered and progressed into apparently functional antral follicles (that is, they produced E2). Total ovarian volume was significantly reduced (30 to 40%) in the high-dose group on day 1, and remained depressed throughout the experiment. Examination of ovarian morphometrics indicated that this volume loss represented specific temporal changes in corpora lutea (CL), interstitial tissue, growing follicles, and antral follicles. At 1 and 3 days after treatment, the major loss in ovarian volume was due to a reduction in antral follicle and interstitial tissue volumes, while at 7 days the majority of volume loss was accounted for by the absence of CL. It is not known if CL are directly affected by CPA at the early time points, but their absence at 7 and 14 days is probably due to earlier destruction of antral follicles. These results demonstrate that CPA-induced ovarian toxicity is exhibited as temporal changes in both structural and functional features of the ovary, particularly in destruction of primordial and antral follicles and depressed E2 production. Information of this type also gives insight into ovarian response to chemical disruption of folliculogenesis and its recovery process." @default.
• W2092114519 created "2016-06-24" @default.
• W2092114519 creator A5072218435 @default.
• W2092114519 creator A5074109809 @default.
• W2092114519 date "1992-09-01" @default.
• W2092114519 modified "2023-10-16" @default.
• W2092114519 title "Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 2. Effects on uterine structure and function" @default.
• W2092114519 cites W1519899626 @default.
• W2092114519 cites W1540046929 @default.
• W2092114519 cites W1542467604 @default.
• W2092114519 cites W1592902627 @default.
• W2092114519 cites W1603047561 @default.
• W2092114519 cites W1608474506 @default.
• W2092114519 cites W1853305117 @default.
• W2092114519 cites W1907235146 @default.
• W2092114519 cites W1936333617 @default.
• W2092114519 cites W1963740910 @default.
• W2092114519 cites W1965431701 @default.
• W2092114519 cites W1974690510 @default.
• W2092114519 cites W1975651370 @default.
• W2092114519 cites W1983106227 @default.
• W2092114519 cites W1992060002 @default.
• W2092114519 cites W1997916347 @default.
• W2092114519 cites W2008531519 @default.
• W2092114519 cites W2017537541 @default.
• W2092114519 cites W2020025712 @default.
• W2092114519 cites W2023817182 @default.
• W2092114519 cites W2031784658 @default.
• W2092114519 cites W2034172400 @default.
• W2092114519 cites W2041968020 @default.
• W2092114519 cites W2042940277 @default.
• W2092114519 cites W2068038734 @default.
• W2092114519 cites W2084360093 @default.
• W2092114519 cites W2091754320 @default.
• W2092114519 cites W2104309683 @default.
• W2092114519 cites W2134422076 @default.
• W2092114519 cites W2162388356 @default.
• W2092114519 cites W2168055229 @default.
• W2092114519 cites W2274370275 @default.
• W2092114519 cites W2335138225 @default.
• W2092114519 cites W34402598 @default.
• W2092114519 cites W1512058680 @default.
• W2092114519 doi "https://doi.org/10.1016/0890-6238(92)90005-e" @default.
• W2092114519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1463922" @default.
• W2092114519 hasPublicationYear "1992" @default.
• W2092114519 type Work @default.
• W2092114519 sameAs 2092114519 @default.
• W2092114519 citedByCount "42" @default.
• W2092114519 countsByYear W20921145192012 @default.
• W2092114519 countsByYear W20921145192013 @default.
• W2092114519 countsByYear W20921145192014 @default.
• W2092114519 countsByYear W20921145192015 @default.
• W2092114519 countsByYear W20921145192017 @default.
• W2092114519 countsByYear W20921145192018 @default.
• W2092114519 countsByYear W20921145192019 @default.
• W2092114519 countsByYear W20921145192020 @default.
• W2092114519 countsByYear W20921145192021 @default.
• W2092114519 countsByYear W20921145192022 @default.
• W2092114519 countsByYear W20921145192023 @default.
• W2092114519 crossrefType "journal-article" @default.
• W2092114519 hasAuthorship W2092114519A5072218435 @default.
• W2092114519 hasAuthorship W2092114519A5074109809 @default.
• W2092114519 hasConcept C102570824 @default.
• W2092114519 hasConcept C126322002 @default.
• W2092114519 hasConcept C134018914 @default.
• W2092114519 hasConcept C142773365 @default.
• W2092114519 hasConcept C16685009 @default.
• W2092114519 hasConcept C179933525 @default.
• W2092114519 hasConcept C196843134 @default.
• W2092114519 hasConcept C2776694085 @default.
• W2092114519 hasConcept C2776755627 @default.
• W2092114519 hasConcept C2778324911 @default.
• W2092114519 hasConcept C2780536345 @default.
• W2092114519 hasConcept C5512455 @default.
• W2092114519 hasConcept C71924100 @default.
• W2092114519 hasConcept C86803240 @default.
• W2092114519 hasConcept C95444343 @default.
• W2092114519 hasConceptScore W2092114519C102570824 @default.
• W2092114519 hasConceptScore W2092114519C126322002 @default.
• W2092114519 hasConceptScore W2092114519C134018914 @default.
• W2092114519 hasConceptScore W2092114519C142773365 @default.
• W2092114519 hasConceptScore W2092114519C16685009 @default.
• W2092114519 hasConceptScore W2092114519C179933525 @default.
• W2092114519 hasConceptScore W2092114519C196843134 @default.
• W2092114519 hasConceptScore W2092114519C2776694085 @default.
• W2092114519 hasConceptScore W2092114519C2776755627 @default.
• W2092114519 hasConceptScore W2092114519C2778324911 @default.
• W2092114519 hasConceptScore W2092114519C2780536345 @default.
• W2092114519 hasConceptScore W2092114519C5512455 @default.
• W2092114519 hasConceptScore W2092114519C71924100 @default.
• W2092114519 hasConceptScore W2092114519C86803240 @default.
• W2092114519 hasConceptScore W2092114519C95444343 @default.
• W2092114519 hasLocation W20921145191 @default.
• W2092114519 hasLocation W20921145192 @default.
• W2092114519 hasOpenAccess W2092114519 @default.
• W2092114519 hasPrimaryLocation W20921145191 @default.
• W2092114519 hasRelatedWork W1975815561 @default.
• W2092114519 hasRelatedWork W1982656190 @default.
• W2092114519 hasRelatedWork W2019990017 @default.
• W2092114519 hasRelatedWork W2068375641 @default.

• next