FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092115220> ?p ?o ?g. }

• W2092115220 abstract "Abstract Since the introduction of opioids as spinally active analgesics into the field of pain research and management, the spinal cord and the peripheral nervous system have been explored for numerous different physiological and pharmacological pain modulating systems. Thereby the use of cholinergic agonists and acetylcholinesterase-inhibitors was investigated with respect to their specific antinociceptive activity, any potential side effects and also with regard to any potential toxicity after their spinal administration. Besides analgesia, spinal cholinergic agonists will also result in motor weakness. Neostigmine, a clinically well-known acetylcholine (ACh)-esterase inhibitor, was found however to result in dose-dependent, potent analgesia after spinal and peripheral administration in preclinical and clinical trials. The clinical studies exploiting spinal or epidural administration of neostigmine revealed an analgesic effect for neostigmine 50–100 μg comparable to that of spinally applied morphine. Neostigmine lacks any neurotoxicity after intrathecal injection, although its spinal and epidural use might be limited by another side effect — the high incidence of nausea and vomiting. Based on the findings of a peripheral analgesic action of opioids, neostigmine's peripheral analgesic effects were also demonstrated in acute pain states. Here it is shown that postoperative analgesia can be accomplished by intra-articular neostigmine and by co-delivery of neostigmine with mepivacaine in axillary plexus blockade. However, further studies on the underlying mechanisms of peripheral antinociception are warranted before the routine clinical use of neostigmine as a peripheral acting analgesic can be recommended. In conclusion, due to its potential side effects, the use of the otherwise very effective spinal analgesic neostigmine will be limited to certain specific pain states or as a co-drug with other analgesics." @default.
• W2092115220 created "2016-06-24" @default.
• W2092115220 creator A5006416309 @default.
• W2092115220 creator A5077105297 @default.
• W2092115220 date "1999-03-01" @default.
• W2092115220 modified "2023-09-27" @default.
• W2092115220 title "The novel analgesic neostigmine and the morning after: Nothing more than sedation, nausea and vomiting?" @default.
• W2092115220 cites W1496572877 @default.
• W2092115220 cites W1968502268 @default.
• W2092115220 cites W1969144595 @default.
• W2092115220 cites W1970215080 @default.
• W2092115220 cites W1970730225 @default.
• W2092115220 cites W1978888644 @default.
• W2092115220 cites W1992723669 @default.
• W2092115220 cites W1996346581 @default.
• W2092115220 cites W2006911376 @default.
• W2092115220 cites W2019533227 @default.
• W2092115220 cites W2025684756 @default.
• W2092115220 cites W2029365474 @default.
• W2092115220 cites W2032873969 @default.
• W2092115220 cites W2033217020 @default.
• W2092115220 cites W2036207561 @default.
• W2092115220 cites W2038168100 @default.
• W2092115220 cites W2039658061 @default.
• W2092115220 cites W2039812684 @default.
• W2092115220 cites W2056341742 @default.
• W2092115220 cites W2061029624 @default.
• W2092115220 cites W2062200486 @default.
• W2092115220 cites W2068575727 @default.
• W2092115220 cites W2072714899 @default.
• W2092115220 cites W2076464326 @default.
• W2092115220 cites W2087708397 @default.
• W2092115220 cites W2098879095 @default.
• W2092115220 cites W2102431832 @default.
• W2092115220 cites W2117390615 @default.
• W2092115220 cites W2118759238 @default.
• W2092115220 cites W2132829674 @default.
• W2092115220 cites W2149086984 @default.
• W2092115220 cites W2151569606 @default.
• W2092115220 cites W2333524834 @default.
• W2092115220 cites W2399453464 @default.
• W2092115220 cites W2408455729 @default.
• W2092115220 cites W2418376877 @default.
• W2092115220 cites W2419339216 @default.
• W2092115220 cites W52465857 @default.
• W2092115220 doi "https://doi.org/10.1016/s1366-0071(99)80034-5" @default.
• W2092115220 hasPublicationYear "1999" @default.
• W2092115220 type Work @default.
• W2092115220 sameAs 2092115220 @default.
• W2092115220 citedByCount "1" @default.
• W2092115220 crossrefType "journal-article" @default.
• W2092115220 hasAuthorship W2092115220A5006416309 @default.
• W2092115220 hasAuthorship W2092115220A5077105297 @default.
• W2092115220 hasConcept C2777411258 @default.
• W2092115220 hasConcept C2780580376 @default.
• W2092115220 hasConcept C2780820201 @default.
• W2092115220 hasConcept C2780852908 @default.
• W2092115220 hasConcept C42219234 @default.
• W2092115220 hasConcept C71924100 @default.
• W2092115220 hasConcept C98274493 @default.
• W2092115220 hasConceptScore W2092115220C2777411258 @default.
• W2092115220 hasConceptScore W2092115220C2780580376 @default.
• W2092115220 hasConceptScore W2092115220C2780820201 @default.
• W2092115220 hasConceptScore W2092115220C2780852908 @default.
• W2092115220 hasConceptScore W2092115220C42219234 @default.
• W2092115220 hasConceptScore W2092115220C71924100 @default.
• W2092115220 hasConceptScore W2092115220C98274493 @default.
• W2092115220 hasLocation W20921152201 @default.
• W2092115220 hasOpenAccess W2092115220 @default.
• W2092115220 hasPrimaryLocation W20921152201 @default.
• W2092115220 hasRelatedWork W1155499590 @default.
• W2092115220 hasRelatedWork W121749347 @default.
• W2092115220 hasRelatedWork W1719046858 @default.
• W2092115220 hasRelatedWork W1811092602 @default.
• W2092115220 hasRelatedWork W1884427778 @default.
• W2092115220 hasRelatedWork W1980629163 @default.
• W2092115220 hasRelatedWork W2005615615 @default.
• W2092115220 hasRelatedWork W204650974 @default.
• W2092115220 hasRelatedWork W2049880422 @default.
• W2092115220 hasRelatedWork W2073937148 @default.
• W2092115220 hasRelatedWork W2077693851 @default.
• W2092115220 hasRelatedWork W2162176555 @default.
• W2092115220 hasRelatedWork W2254111948 @default.
• W2092115220 hasRelatedWork W2409426502 @default.
• W2092115220 hasRelatedWork W2410979022 @default.
• W2092115220 hasRelatedWork W2424116383 @default.
• W2092115220 hasRelatedWork W2477216150 @default.
• W2092115220 hasRelatedWork W2971009730 @default.
• W2092115220 hasRelatedWork W79449778 @default.
• W2092115220 hasRelatedWork W948207093 @default.
• W2092115220 isParatext "false" @default.
• W2092115220 isRetracted "false" @default.
• W2092115220 magId "2092115220" @default.
• W2092115220 workType "article" @default.