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• W2092115424 abstract "CNS OncologyVol. 3, No. 2 EditorialPrioritizing uncharacterized genes in the search for glioma biomarkersRheal A Towner, Jonathan D WrenRheal A Towner* Author for correspondence: E-mail Address: rheal-towner@omrf.org Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13 Street, Oklahoma City, OK 73104, USA Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USASearch for more papers by this author, Jonathan D Wren Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USASearch for more papers by this authorPublished Online:28 Apr 2014https://doi.org/10.2217/cns.14.8AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: bioinformaticsbiomarkercancerdiagnosticsgliomaprognosticstherapeuticsReferences1 Central Brain Tumor Registry of the United States. 2011 CBTRUS Statistical Report: Primary brain and central Nervous System Tumors Diagnosed in the United States in 2004–2007 (2011). www.cbtrus.org/2011-NPCR-SEER/WEB-0407-Report-3-3-2011.pdfGoogle Scholar2 Louis DN. Molecular pathology of malignant gliomas. Annu. Rev. Pathol. 1, 97–117 (2006).Crossref, Medline, CAS, Google Scholar3 The Cancer Genome Atlas (TCGA) Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061–1068 (2008).Crossref, Medline, CAS, Google Scholar4 Riemenschneider MJ, Jeuken JWM, Wesseling P, Reifenberger G. Molecular diagnostics of gliomas: state of the art. Acta Neuropathol. 120, 567–584 (2010).Crossref, Medline, CAS, Google Scholar5 Jansen M, Yip S, Louis DN. Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers. Lancet Neurol. 9, 717–726 (2010).Crossref, Medline, CAS, Google Scholar6 Colman H, Zhang L, Sulman EP et al. A multigene predictor of outcome in glioblastoma. Neuro Oncol. 12, 49–57 (2010).Crossref, Medline, CAS, Google Scholar7 Farias-Eisner G, Bank AM, Hwang BY et al. Glioblastoma biomarkers from bench to bedside: advances and challenges. Br. J. Neurosurg. 26, 189–194 (2012).Crossref, Medline, Google Scholar8 Parsons DW, Jones S, Zhang X et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008).Crossref, Medline, CAS, Google Scholar9 Silber JR, Bobola MS, Blank A, Chamberlain MC. O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems. Biochim. Biophys. Acta 1826, 71–82 (2012).Medline, CAS, Google Scholar10 Niclou SP, Fack F, Rajcevic U. Glioma proteomics: status and perspectives. J. Proteomics 73, 1823–1838 (2010).Crossref, Medline, CAS, Google Scholar11 Wren JD. A global meta-analysis of microarray expression data to predict unknown gene functions and estimate the literature-data divide. Bioinformatics 25, 1694–1701 (2009).Crossref, Medline, CAS, Google Scholar12 Giles CB, Wren JD. Large-scale directional relationship extraction and resolution. BMC Bioinformatics 9(Suppl. 9), S11 (2008).Crossref, Medline, Google Scholar13 Wren JD. Extending the mutual information measure to rank inferred literature relationships. BMC Bioinformatics 5, 145 (2004).Crossref, Medline, Google Scholar14 Towner RA, Jensen RL, Colman H et al. ELTD1, a potential new biomarker for gliomas. Neurosurgery 72, 77–91 (2013).Crossref, Medline, Google Scholar15 Towner RA, Jensen RL, Vaillant B et al. Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro-Oncology 15, 1625–1634 (2013).Crossref, Medline, CAS, Google Scholar16 Leavy O. Therapeutic antibodies: past, present and future. Nat. Rev. Immunol. 10(5), 297 (2010).Crossref, Medline, CAS, Google Scholar17 Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH. Too many roads not taken. Nature 470, 163–165 (2011).Crossref, Medline, CAS, Google Scholar18 Barrett T, Wilhite SE, Ledoux P et al. NCBI GEO: archive for functional genomics data sets–update. Nucleic Acids Res. 41, D991–D995 (2013).Crossref, Medline, CAS, Google Scholar19 Gillis J, Pavlidis P. The impact of multifunctional genes on ‘guilt by association’ analysis. PLoS ONE 6, e17258 (2011).Crossref, Medline, CAS, Google Scholar20 Gillis J, Pavlidis P. ‘Guilt by association’ is the exception rather than the rule in gene networks. PLoS Comput. Biol. 8, e1002444 (2012).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByThe second annual conference of International ovarian cancer consortium and the symposium on tumor microenvironment and therapeutic resistanceGenes & Cancer, Vol. 7, No. 1-2Prospective evaluation of protein C and factor VIII in prediction of cancer-associated thrombosisThrombosis Research, Vol. 136, No. 6 Vol. 3, No. 2 Follow us on social media for the latest updates Metrics Downloaded 35 times History Published online 28 April 2014 Published in print March 2014 Information© Future Medicine LtdKeywordsbioinformaticsbiomarkercancerdiagnosticsgliomaprognosticstherapeuticsFinancial & competing interests disclosureThe research published in references [14,15] was supported by the Oklahoma Medical Research Foundation (to RA Towner), the Chapman Foundation (to JD Wren) and NIH grants 1P20GM103636 and 8P20GM103456-09 (to JD Wren). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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