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- W2092115674 abstract "Two toxicity experiments were carried out with the β-isomer of hexachlorocyclohexane (β-HCH) in the Japanese ricefish (medaka, Oryzias latipes). The experiments were started with freshly fertilized eggs (Exp. 1) or with young fish (1 mth post hatching) (Exp. II). The concentration of β-HCH ranged from 0.032–1.0 mg/l tank water. After 1 and 3 mth histopathological examination was carried out, which revealed development of testis-ova (intersexuality, hermaphroditism) in males and induction of vitellogenesis in either sex after 3 mth. These features are characteristic of estrogen-like activity. In addition, after 1 and 3 mth heterotopic development of adipose tissue (lipomatosis) was observed in parenchymal organs (liver, kidney, testis) which in the liver was associated with multilocular dilations of the interstitium (spongiotic edema) in Exp. I. In this experiment, the vacuolation of liver cells was also increased, which electronmicroscopically appeared to be due to accumulation of glycogen. In the thyroid follicles the epithelial cells showed hypertrophy and the colloid content was diminished; moreover, the number of thyrotropic hormone-producing cells in the pituitary was increased. These observations are indicative of a high level of activity of the thyroid. In the kidneys accumulation of amorphous eosinophilic precipitate in the glomeruli (glomerular hyalinosis) was prominent, and a similar precipitate could be found around the liver sinusoids and the splenic capsule; the nature of this precipitate could not be determined histochemically and electronmicroscopically. It is concluded that β-HCH has multiple toxic effects in medakas, some of which yield evidence for an estrogen-like activity, as is also found in guppies and rodents. Exposure for 1 or 3 mth in both experiments produced no-effect concentrations of 0.056 and 0.1 mg β-HCH/1 respectively." @default.
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- W2092115674 date "1986-10-01" @default.
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- W2092115674 title "Histopathological study of Oryzias latipes (medaka) after long-term β-hexachlorocyclohexane exposure" @default.
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- W2092115674 doi "https://doi.org/10.1016/0166-445x(86)90004-4" @default.
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