Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092115964> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2092115964 endingPage "1018" @default.
- W2092115964 startingPage "1009" @default.
- W2092115964 abstract "Antisense phosphorodiamidate Morpholino oligomers (PMO) are resistant to degradation by cellular hydrolases, DNases, RNases, and phosphodiesterases, but remain sensitive to prolonged exposure to low pH. The present studies evaluate the oral fractional bioavailability, stability, and efficacy of two distinct PMO sequences targeted to c-myc and cytochrome P-450 (CYP) 3A2. The c-myc antisense 20-mer, AVI-4126 (5'-ACGTTGAGGGGCATCGTCGC-3'), slowed the regenerative process in the rat liver after a 70% partial hepatectomy (PH). Rats were administered 3.0 mg/kg AVI-4126 in 0.1 mL saline via a bolus intravenous injection or in 0.5 mL sterile phosphate-buffered saline via gavage immediately following PH. The areas under the plasma concentration versus time curves revealed a fractional oral availability of 78.8% over a period of 10 min through 24 h. Immunoblot analysis of liver tissue from rats treated orally with AVI-4126 demonstrated a sequence-specific reduction in the target protein c-Myc, as well as secondary proliferation markers: proliferating cell nuclear antigen (PCNA), cyclin D1, and p53. The CYP3A2 antisense 22-mer AVI-4472 (5'-GAGCTGAAAGCAGGTCCATCCC-3') caused a sequence-dependent reduction of approximately five-fold in the rat liver CYP3A2 protein levels and erythromycin demethylation activity in 24 h following oral administration at a dose of 2 mg/kg. It is concluded that oral administration of PMOs can inhibit c-myc and CYP3A2 gene expression in rat liver by an antisense-based mechanism of action. These studies highlight the potential for development of PMOs as orally administered therapeutic agents." @default.
- W2092115964 created "2016-06-24" @default.
- W2092115964 creator A5016170187 @default.
- W2092115964 creator A5059176142 @default.
- W2092115964 creator A5078137518 @default.
- W2092115964 creator A5082192456 @default.
- W2092115964 creator A5090881808 @default.
- W2092115964 date "2002-04-01" @default.
- W2092115964 modified "2023-09-26" @default.
- W2092115964 title "Bioavailability and Efficacy of Antisense Morpholino Oligomers Targeted to c-myc and Cytochrome P-450 3A2 Following Oral Administration in Rats" @default.
- W2092115964 cites W1593266148 @default.
- W2092115964 cites W1967028954 @default.
- W2092115964 cites W1979596837 @default.
- W2092115964 cites W1994060367 @default.
- W2092115964 cites W1994489381 @default.
- W2092115964 cites W2010513203 @default.
- W2092115964 cites W2037173705 @default.
- W2092115964 cites W2071230707 @default.
- W2092115964 cites W2073859633 @default.
- W2092115964 cites W2079142406 @default.
- W2092115964 cites W2084929175 @default.
- W2092115964 cites W2113117576 @default.
- W2092115964 cites W2119792005 @default.
- W2092115964 cites W2147475770 @default.
- W2092115964 cites W2174933528 @default.
- W2092115964 cites W2184051949 @default.
- W2092115964 cites W30796483 @default.
- W2092115964 cites W4211173486 @default.
- W2092115964 cites W4240204112 @default.
- W2092115964 doi "https://doi.org/10.1002/jps.10088" @default.
- W2092115964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11948540" @default.
- W2092115964 hasPublicationYear "2002" @default.
- W2092115964 type Work @default.
- W2092115964 sameAs 2092115964 @default.
- W2092115964 citedByCount "70" @default.
- W2092115964 countsByYear W20921159642012 @default.
- W2092115964 countsByYear W20921159642013 @default.
- W2092115964 countsByYear W20921159642014 @default.
- W2092115964 countsByYear W20921159642015 @default.
- W2092115964 countsByYear W20921159642016 @default.
- W2092115964 countsByYear W20921159642018 @default.
- W2092115964 countsByYear W20921159642019 @default.
- W2092115964 countsByYear W20921159642020 @default.
- W2092115964 countsByYear W20921159642021 @default.
- W2092115964 countsByYear W20921159642022 @default.
- W2092115964 countsByYear W20921159642023 @default.
- W2092115964 crossrefType "journal-article" @default.
- W2092115964 hasAuthorship W2092115964A5016170187 @default.
- W2092115964 hasAuthorship W2092115964A5059176142 @default.
- W2092115964 hasAuthorship W2092115964A5078137518 @default.
- W2092115964 hasAuthorship W2092115964A5082192456 @default.
- W2092115964 hasAuthorship W2092115964A5090881808 @default.
- W2092115964 hasConcept C136571751 @default.
- W2092115964 hasConcept C153911025 @default.
- W2092115964 hasConcept C173396325 @default.
- W2092115964 hasConcept C181389837 @default.
- W2092115964 hasConcept C185592680 @default.
- W2092115964 hasConcept C190283241 @default.
- W2092115964 hasConcept C2777056448 @default.
- W2092115964 hasConcept C34688535 @default.
- W2092115964 hasConcept C55493867 @default.
- W2092115964 hasConcept C62112901 @default.
- W2092115964 hasConcept C86803240 @default.
- W2092115964 hasConcept C98274493 @default.
- W2092115964 hasConceptScore W2092115964C136571751 @default.
- W2092115964 hasConceptScore W2092115964C153911025 @default.
- W2092115964 hasConceptScore W2092115964C173396325 @default.
- W2092115964 hasConceptScore W2092115964C181389837 @default.
- W2092115964 hasConceptScore W2092115964C185592680 @default.
- W2092115964 hasConceptScore W2092115964C190283241 @default.
- W2092115964 hasConceptScore W2092115964C2777056448 @default.
- W2092115964 hasConceptScore W2092115964C34688535 @default.
- W2092115964 hasConceptScore W2092115964C55493867 @default.
- W2092115964 hasConceptScore W2092115964C62112901 @default.
- W2092115964 hasConceptScore W2092115964C86803240 @default.
- W2092115964 hasConceptScore W2092115964C98274493 @default.
- W2092115964 hasIssue "4" @default.
- W2092115964 hasLocation W20921159641 @default.
- W2092115964 hasLocation W20921159642 @default.
- W2092115964 hasOpenAccess W2092115964 @default.
- W2092115964 hasPrimaryLocation W20921159641 @default.
- W2092115964 hasRelatedWork W1511489281 @default.
- W2092115964 hasRelatedWork W190801549 @default.
- W2092115964 hasRelatedWork W1970331292 @default.
- W2092115964 hasRelatedWork W2025300196 @default.
- W2092115964 hasRelatedWork W2086460393 @default.
- W2092115964 hasRelatedWork W2314489661 @default.
- W2092115964 hasRelatedWork W2317627837 @default.
- W2092115964 hasRelatedWork W2414263157 @default.
- W2092115964 hasRelatedWork W4238545538 @default.
- W2092115964 hasRelatedWork W88005891 @default.
- W2092115964 hasVolume "91" @default.
- W2092115964 isParatext "false" @default.
- W2092115964 isRetracted "false" @default.
- W2092115964 magId "2092115964" @default.
- W2092115964 workType "article" @default.