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• W2092116018 startingPage "1752" @default.
• W2092116018 abstract "Diverse functionalized representatives of various classes of sugars, such as thio-, anhydro-, and sulfamido-sugars and myo-inositol oxide, were synthesized and assessed for cytotoxicity against human cancer cell lines (A549, LoVo, MCF-7 and HeLa). The inositol oxide (4) was more active against MCF-7 cells (i.e., an estrogen-dependent breast cancer line), whereas all 3 sulfur-containing compounds showed strongest activity against A549 cells (i.e., a lung adenocarcinoma line). We propose to use a concept of functional 'CARB-pharmacophores' when evaluating a potential for the compounds' general antineoplastic activity. Future studies will determine the reasons for cell-type specificity of these compounds. The thio-sugar motif appears to be a promising lead for future developments." @default.
• W2092116018 created "2016-06-24" @default.
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• W2092116018 date "2014-04-01" @default.
• W2092116018 modified "2023-09-29" @default.
• W2092116018 title "A potential CARB-pharmacophore for antineoplastic activity: Part 1" @default.
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• W2092116018 doi "https://doi.org/10.1016/j.bmcl.2014.02.036" @default.
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