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- W2092116368 abstract "In today's Lancet, Giuseppe Remuzzi and colleagues report a provocative study that challenges the belief that mycophenolate mofetil improves outcome in kidney transplantation. They looked at two different immunosuppressive regimens in first-time-transplant recipients of a kidney from a cadaver, at 0–6 months (phase A) and 7–21 months (phase B) after transplantation with steroid withdrawal over months 7–9. One group was randomised to receive mycophenolate mofetil, the other group received azathioprine. The results were similar for number and severity of rejection episodes, creatinine concentrations, and adverse events. Because mycophenolate mofetil costs about 15 times more than azathioprine, Remuzzi and colleagues suggest that substantial cost savings could be made by using azathioprine, which has been available for several decades and used since the early days of clinical transplantation. Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trialIn recipients of cadaver kidney-transplants given ciclosporin microemulsion, mycophenolate mofetil offers no advantages over azathioprine in preventing acute rejections and is about 15 times more expensive. Standard immunosuppression regimens for transplantation should perhaps include azathioprine rather than mycophenolate mofetil, at least for kidney grafts. Full-Text PDF" @default.
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- W2092116368 date "2004-08-01" @default.
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- W2092116368 title "Show me the money—immunosuppression in kidney transplantation" @default.
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- W2092116368 doi "https://doi.org/10.1016/s0140-6736(04)16822-0" @default.
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