FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092116576> ?p ?o ?g. }

• W2092116576 endingPage "2134" @default.
• W2092116576 startingPage "2129" @default.
• W2092116576 abstract "Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate (DEHA) has been achieved using primary hepatocyte cultures derived from different species and cyanide-insensitive fatty acyl CoA oxidase (PCO) as a marker enzyme for peroxisome proliferation. In rat and mouse hepatocytes, the parent compound (DEHA) had no effect on peroxisomal β-oxidation, but primary metabolites of DEHA, mono (2-ethylhexyl) adipate (MEHA) and 2-ethylhexanol (EH), were approximately equipotent in PCO induction (5-fold at 0.5 mM final concentration). The secondary metabolite of DEHA, 2-ethylhexanoic acid (EHA), was in both species the most potent peroxisome proliferator (25- and 9-fold induction in mice and rats, respectively, at 1 mM final concentration). At 2 mM final concentration a tertiary metabolite of DEHA, 2-ethyl-5-hydroxyhexan-1-oic acid, was less effective in mouse and rat hepatocytes at inducing PCO (15- and 5-fold, respectively). 2-Ethyl-5-oxohexan-1-oic acid and 2-ethylhexan-l,6-dioic acid had little effect (2-3-fold in both rat and mouse hepatocytes). Thus, EHA was identified as the proximate peroxisome proliferator of DEHA and mouse hepatocytes were approximately twice as sensitive as rat hepatocytes to peroxisome proliferation due to MEHA, EH and EHA. We investigated further species differences in response to peroxisome proliferators by using guinea pig and marmoset primary hepatocyte culture. None of the chemicals studied stimulated peroxisomal β-oxidation in these species up to a final concentration of 2 mM. Higher concentrations lead to cytotoxicity. This lack of sensitivity of guinea pig and marmoset hepatocytes is in agreement with previous studies with di (2-ethylhexyl) phthalate metabolites, suggesting the absence of a threat of hepatocarcinogenic damage to these species and confirming that primary hepatocytes cultures are useful models for investigating the phenomenon of peroxisome proliferation." @default.
• W2092116576 created "2016-06-24" @default.
• W2092116576 creator A5004672953 @default.
• W2092116576 creator A5024501212 @default.
• W2092116576 creator A5025262356 @default.
• W2092116576 creator A5065077745 @default.
• W2092116576 creator A5090378118 @default.
• W2092116576 date "1992-05-01" @default.
• W2092116576 modified "2023-10-11" @default.
• W2092116576 title "Identification of the proximate peroxisome proliferator(S) derived from DI (2-ethylhexyl) adipate and species differences in response" @default.
• W2092116576 cites W1775749144 @default.
• W2092116576 cites W19140683 @default.
• W2092116576 cites W1988565626 @default.
• W2092116576 cites W1992295823 @default.
• W2092116576 cites W1996520281 @default.
• W2092116576 cites W1999982978 @default.
• W2092116576 cites W2002611417 @default.
• W2092116576 cites W2005807397 @default.
• W2092116576 cites W2034199374 @default.
• W2092116576 cites W2037060949 @default.
• W2092116576 cites W2040918147 @default.
• W2092116576 cites W2060874278 @default.
• W2092116576 cites W2079270466 @default.
• W2092116576 cites W2083352982 @default.
• W2092116576 cites W2087936004 @default.
• W2092116576 cites W2090363138 @default.
• W2092116576 cites W2109717067 @default.
• W2092116576 cites W2130219484 @default.
• W2092116576 cites W2219509325 @default.
• W2092116576 doi "https://doi.org/10.1016/0006-2952(92)90171-e" @default.
• W2092116576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1599500" @default.
• W2092116576 hasPublicationYear "1992" @default.
• W2092116576 type Work @default.
• W2092116576 sameAs 2092116576 @default.
• W2092116576 citedByCount "29" @default.
• W2092116576 countsByYear W20921165762012 @default.
• W2092116576 countsByYear W20921165762013 @default.
• W2092116576 countsByYear W20921165762016 @default.
• W2092116576 countsByYear W20921165762019 @default.
• W2092116576 crossrefType "journal-article" @default.
• W2092116576 hasAuthorship W2092116576A5004672953 @default.
• W2092116576 hasAuthorship W2092116576A5024501212 @default.
• W2092116576 hasAuthorship W2092116576A5025262356 @default.
• W2092116576 hasAuthorship W2092116576A5065077745 @default.
• W2092116576 hasAuthorship W2092116576A5090378118 @default.
• W2092116576 hasConcept C104317684 @default.
• W2092116576 hasConcept C12296475 @default.
• W2092116576 hasConcept C127078168 @default.
• W2092116576 hasConcept C170493617 @default.
• W2092116576 hasConcept C181199279 @default.
• W2092116576 hasConcept C185592680 @default.
• W2092116576 hasConcept C188027245 @default.
• W2092116576 hasConcept C188413054 @default.
• W2092116576 hasConcept C202751555 @default.
• W2092116576 hasConcept C2776200302 @default.
• W2092116576 hasConcept C2777075361 @default.
• W2092116576 hasConcept C2777477808 @default.
• W2092116576 hasConcept C38485361 @default.
• W2092116576 hasConcept C55493867 @default.
• W2092116576 hasConcept C63932345 @default.
• W2092116576 hasConcept C86339819 @default.
• W2092116576 hasConcept C86803240 @default.
• W2092116576 hasConceptScore W2092116576C104317684 @default.
• W2092116576 hasConceptScore W2092116576C12296475 @default.
• W2092116576 hasConceptScore W2092116576C127078168 @default.
• W2092116576 hasConceptScore W2092116576C170493617 @default.
• W2092116576 hasConceptScore W2092116576C181199279 @default.
• W2092116576 hasConceptScore W2092116576C185592680 @default.
• W2092116576 hasConceptScore W2092116576C188027245 @default.
• W2092116576 hasConceptScore W2092116576C188413054 @default.
• W2092116576 hasConceptScore W2092116576C202751555 @default.
• W2092116576 hasConceptScore W2092116576C2776200302 @default.
• W2092116576 hasConceptScore W2092116576C2777075361 @default.
• W2092116576 hasConceptScore W2092116576C2777477808 @default.
• W2092116576 hasConceptScore W2092116576C38485361 @default.
• W2092116576 hasConceptScore W2092116576C55493867 @default.
• W2092116576 hasConceptScore W2092116576C63932345 @default.
• W2092116576 hasConceptScore W2092116576C86339819 @default.
• W2092116576 hasConceptScore W2092116576C86803240 @default.
• W2092116576 hasIssue "10" @default.
• W2092116576 hasLocation W20921165761 @default.
• W2092116576 hasLocation W20921165762 @default.
• W2092116576 hasLocation W20921165763 @default.
• W2092116576 hasOpenAccess W2092116576 @default.
• W2092116576 hasPrimaryLocation W20921165761 @default.
• W2092116576 hasRelatedWork W2015764278 @default.
• W2092116576 hasRelatedWork W2041577006 @default.
• W2092116576 hasRelatedWork W2067421512 @default.
• W2092116576 hasRelatedWork W2076085251 @default.
• W2092116576 hasRelatedWork W208063806 @default.
• W2092116576 hasRelatedWork W257882641 @default.
• W2092116576 hasRelatedWork W343477878 @default.
• W2092116576 hasRelatedWork W56166758 @default.
• W2092116576 hasRelatedWork W811837610 @default.
• W2092116576 hasRelatedWork W2415030307 @default.
• W2092116576 hasVolume "43" @default.
• W2092116576 isParatext "false" @default.
• W2092116576 isRetracted "false" @default.

• next