Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092116722> ?p ?o ?g. }
- W2092116722 endingPage "439" @default.
- W2092116722 startingPage "435" @default.
- W2092116722 abstract "The efficacy of the standard hepatitis B virus (HBV) vaccination schedule in individuals with chronic hepatitis C is reported to be reduced. Our aim was to assess the response rate to high dose, short interval HBV vaccination in such individuals.A total of 152 individuals with chronic hepatitis C were vaccinated with 40 microg of vaccine administered monthly for 3 months. Twenty-six individuals with no evidence of liver disease underwent the same vaccination schedule and were considered to be the control group. Hepatitis C virus (HCV)-positive subjects who did not seroconvert to anti-hepatitis B surface positivity after the third dose of the vaccine (nonresponder) were vaccinated with a fourth dose of vaccine (booster dose, 80 microg).One hundred nine of the 152 individuals with chronic hepatitis C (72%) seroconverted to anti-hepatitis B surface positivity (> 10 mIU/ml), as compared to 24 of the 26 controls (92%, p < 0.05). Although individuals with chronic hepatitis C responded less frequently to high dose, short interval HBV vaccination than did the controls, no differences in terms of effective immunity (>100 mIU/ml) were evident among the two groups of responders (51% vs 54%). Also, no difference in response was reported between individuals with chronic active hepatitis C and controls (92% vs 80%). The response rate was significantly lower in cirrhotics than in the noncirrhotic group (54% vs 80%, p < 0.001). Besides cirrhosis, no other demographic or bioclinical factor was found to influence the response to vaccination. After the additional booster dose, the overall response was increased to 74% of the cirrhotics and 88% of the noncirrhotics. No major HBV vaccine-related adverse effects were seen.A high dose, short interval HBV vaccination schedule is safe in individuals with chronic hepatitis C. From these data, it is suggested that a high dose and a short interval between HBV vaccinations may produce an effective and early antibody response in such patients." @default.
- W2092116722 created "2016-06-24" @default.
- W2092116722 creator A5024092214 @default.
- W2092116722 creator A5024151665 @default.
- W2092116722 creator A5030413648 @default.
- W2092116722 creator A5032714638 @default.
- W2092116722 creator A5063035565 @default.
- W2092116722 date "2002-02-01" @default.
- W2092116722 modified "2023-10-10" @default.
- W2092116722 title "The effect of high dose and short interval HBV vaccination in individuals with chronic hepatitis C" @default.
- W2092116722 cites W1963912221 @default.
- W2092116722 cites W1964037914 @default.
- W2092116722 cites W1964834554 @default.
- W2092116722 cites W1981371678 @default.
- W2092116722 cites W1989589428 @default.
- W2092116722 cites W2001897672 @default.
- W2092116722 cites W2015885165 @default.
- W2092116722 cites W2020669141 @default.
- W2092116722 cites W2027616397 @default.
- W2092116722 cites W2042595944 @default.
- W2092116722 cites W2054482266 @default.
- W2092116722 cites W2057090440 @default.
- W2092116722 cites W2072765280 @default.
- W2092116722 cites W2078867302 @default.
- W2092116722 cites W2107560605 @default.
- W2092116722 cites W2120128540 @default.
- W2092116722 cites W2128817439 @default.
- W2092116722 cites W2130416358 @default.
- W2092116722 cites W2160544967 @default.
- W2092116722 cites W2336049787 @default.
- W2092116722 cites W2437864828 @default.
- W2092116722 cites W4237427832 @default.
- W2092116722 cites W4250822829 @default.
- W2092116722 cites W4254366687 @default.
- W2092116722 doi "https://doi.org/10.1111/j.1572-0241.2002.05482.x" @default.
- W2092116722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11866284" @default.
- W2092116722 hasPublicationYear "2002" @default.
- W2092116722 type Work @default.
- W2092116722 sameAs 2092116722 @default.
- W2092116722 citedByCount "52" @default.
- W2092116722 countsByYear W20921167222012 @default.
- W2092116722 countsByYear W20921167222014 @default.
- W2092116722 countsByYear W20921167222015 @default.
- W2092116722 countsByYear W20921167222016 @default.
- W2092116722 countsByYear W20921167222017 @default.
- W2092116722 countsByYear W20921167222018 @default.
- W2092116722 countsByYear W20921167222019 @default.
- W2092116722 countsByYear W20921167222020 @default.
- W2092116722 countsByYear W20921167222022 @default.
- W2092116722 countsByYear W20921167222023 @default.
- W2092116722 crossrefType "journal-article" @default.
- W2092116722 hasAuthorship W2092116722A5024092214 @default.
- W2092116722 hasAuthorship W2092116722A5024151665 @default.
- W2092116722 hasAuthorship W2092116722A5030413648 @default.
- W2092116722 hasAuthorship W2092116722A5032714638 @default.
- W2092116722 hasAuthorship W2092116722A5063035565 @default.
- W2092116722 hasConcept C12590561 @default.
- W2092116722 hasConcept C126322002 @default.
- W2092116722 hasConcept C159654299 @default.
- W2092116722 hasConcept C203014093 @default.
- W2092116722 hasConcept C22070199 @default.
- W2092116722 hasConcept C2522874641 @default.
- W2092116722 hasConcept C2775876817 @default.
- W2092116722 hasConcept C2776029263 @default.
- W2092116722 hasConcept C2777214474 @default.
- W2092116722 hasConcept C2777382497 @default.
- W2092116722 hasConcept C2777410769 @default.
- W2092116722 hasConcept C2780593183 @default.
- W2092116722 hasConcept C2780791431 @default.
- W2092116722 hasConcept C2780799908 @default.
- W2092116722 hasConcept C2780801004 @default.
- W2092116722 hasConcept C2781037505 @default.
- W2092116722 hasConcept C32611913 @default.
- W2092116722 hasConcept C71924100 @default.
- W2092116722 hasConcept C90924648 @default.
- W2092116722 hasConceptScore W2092116722C12590561 @default.
- W2092116722 hasConceptScore W2092116722C126322002 @default.
- W2092116722 hasConceptScore W2092116722C159654299 @default.
- W2092116722 hasConceptScore W2092116722C203014093 @default.
- W2092116722 hasConceptScore W2092116722C22070199 @default.
- W2092116722 hasConceptScore W2092116722C2522874641 @default.
- W2092116722 hasConceptScore W2092116722C2775876817 @default.
- W2092116722 hasConceptScore W2092116722C2776029263 @default.
- W2092116722 hasConceptScore W2092116722C2777214474 @default.
- W2092116722 hasConceptScore W2092116722C2777382497 @default.
- W2092116722 hasConceptScore W2092116722C2777410769 @default.
- W2092116722 hasConceptScore W2092116722C2780593183 @default.
- W2092116722 hasConceptScore W2092116722C2780791431 @default.
- W2092116722 hasConceptScore W2092116722C2780799908 @default.
- W2092116722 hasConceptScore W2092116722C2780801004 @default.
- W2092116722 hasConceptScore W2092116722C2781037505 @default.
- W2092116722 hasConceptScore W2092116722C32611913 @default.
- W2092116722 hasConceptScore W2092116722C71924100 @default.
- W2092116722 hasConceptScore W2092116722C90924648 @default.
- W2092116722 hasIssue "2" @default.
- W2092116722 hasLocation W20921167221 @default.
- W2092116722 hasLocation W20921167222 @default.
- W2092116722 hasOpenAccess W2092116722 @default.