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- W2092116863 abstract "1. 1. Thyroid glands excised from the fetuses of 21-day pregnant rats were cultured for four days in four different media: a basal medium; the basal medium to which insulin alone was added; the basal medium to whch thyrotropic hormone (TSH) alone was added; and the basal medium to which both TSH and insulin were added. 2. 2. Addition of insulin to the basal medium enhanced significantly the incorporation of 131 I into protein-bound monoiodotyrosine, diiodotyrosine and thyrosine. 3. 3. Addition of TSH to the basal medium, as reported earlier for thyroid glands removed from younger fetuses (16–16.5 and 17–17.5 days of pregnancy), had a pronounced effect on the functional activity of the embryonic thyroid glands explanted into culture. The addition of insulin to the TSH-containing medium further enhanced the 131 I utilization by the embryonic thyroid tissue, the formations of diiodotyrosine and thyroxine being particularly affected. 4. 4. The significance of this action of insulin is discussed." @default.
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- W2092116863 date "1965-12-01" @default.
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- W2092116863 title "The effect of insulin on iodine metabolism of fetal thyroid glands in organ culture" @default.
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- W2092116863 doi "https://doi.org/10.1016/0304-4165(65)90052-8" @default.
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