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• W2092124228 endingPage "433" @default.
• W2092124228 startingPage "419" @default.
• W2092124228 abstract "Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion. In the present review, we discuss how their structure appears to support this function as well as how they are assembled and down-regulated. Desmosomal components also have signalling functions that are important in tissue development and remodelling. Their adhesive and signalling functions are both compromised in genetic and autoimmune diseases that affect the heart, skin and mucous membranes. We conclude that much work is required on structure–function relationships within desmosomes in vivo and on how they participate in signalling processes to enhance our knowledge of tissue homoeostasis and human disease." @default.
• W2092124228 created "2016-06-24" @default.
• W2092124228 creator A5016413440 @default.
• W2092124228 creator A5032268819 @default.
• W2092124228 creator A5064842403 @default.
• W2092124228 creator A5081261971 @default.
• W2092124228 date "2010-07-14" @default.
• W2092124228 modified "2023-09-27" @default.
• W2092124228 title "Desmosomes: adhesive strength and signalling in health and disease" @default.
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