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- W2092125829 abstract "Pom121 is one of the integral membrane components of the nuclear pore complex (NPC) in vertebrate cells. Unlike rodent cells carrying a single POM121 gene, human cells possess multiple POM121 gene loci on chromosome 7q11.23, as a consequence of complex segmental-duplications in this region during human evolution. In HeLa cells, two full-length Pom121 are transcribed and translated by two distinct genetic loci. RNAi experiments showed that efficient depletion of both Pom121 proteins significantly reduces assembled NPCs on nuclear envelope. Pom121-depletion also induced clustering of NPCs, indicating its role on maintenance of NPC structure/organization." @default.
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- W2092125829 date "2007-09-21" @default.
- W2092125829 modified "2023-10-17" @default.
- W2092125829 title "Two distinct human POM121 genes: Requirement for the formation of nuclear pore complexes" @default.
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- W2092125829 doi "https://doi.org/10.1016/j.febslet.2007.09.021" @default.
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