Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092130014> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2092130014 endingPage "69" @default.
- W2092130014 startingPage "64" @default.
- W2092130014 abstract "The convulsant methionine sulfoximine is a potent glycogenic agent in the central nervous system of rodents in vivo. This investigation was undertaken to look for the basic mechanism underlying this property. Astrocytes were cultivated from newborn rat neopallium and glycogen was studied by both biochemical and ultrastructural methods. When the astrocytes were incubated in a medium containing 5.55 mM glucose, methionine sulfoximine (0.55 mM) induced a significant increase in their glycogen content. Glucose content did not change in astrocytes, but it diminished in the medium in all cases. When the decrease in glucose level in the medium was limited, the same glycogenic effects of methionine sulfoximine were observed, but the glycogen contents were higher. The augmentation of the concentration of the convulsant enhanced its glycogenic effect, but this was not directly dose dependent. When the flat and polygonal astrocytes were transformed into process-bearing astrocytes by dibutyryl cyclic AMP methionine sulfoximine always induced an increase in glycogen content. In this case, the values of glycogen contents were lower. In electron microscopy, no glycogen particles were present in the astrocytes even after methionine sulfoximine treatment, contrary to the case in vivo. These results show that the convulsant does not need the presence of neuronal cells to induce glycogen accumulation and that astrocytes may be the direct cell targets. The apparent discrepancy between the biochemical and ultrastructural data is probably due to the relatively low concentration of glycogen in cultured astrocytes." @default.
- W2092130014 created "2016-06-24" @default.
- W2092130014 creator A5025292916 @default.
- W2092130014 creator A5027094294 @default.
- W2092130014 date "1991-01-01" @default.
- W2092130014 modified "2023-09-24" @default.
- W2092130014 title "Biochemical and ultrastructural study of glycogen in cultured astrocytes submitted to the convulsant methionine sulfoximine" @default.
- W2092130014 cites W1498418139 @default.
- W2092130014 cites W1775749144 @default.
- W2092130014 cites W1969381712 @default.
- W2092130014 cites W1980573610 @default.
- W2092130014 cites W1987709959 @default.
- W2092130014 cites W1989865087 @default.
- W2092130014 cites W2004935322 @default.
- W2092130014 cites W2012804122 @default.
- W2092130014 cites W2013195856 @default.
- W2092130014 cites W2027231840 @default.
- W2092130014 cites W2041257397 @default.
- W2092130014 cites W2055598466 @default.
- W2092130014 cites W2058392564 @default.
- W2092130014 cites W2062924373 @default.
- W2092130014 cites W2072353451 @default.
- W2092130014 cites W2074016932 @default.
- W2092130014 cites W2079161852 @default.
- W2092130014 cites W2083132249 @default.
- W2092130014 cites W2084962907 @default.
- W2092130014 cites W2088607053 @default.
- W2092130014 cites W2090237801 @default.
- W2092130014 cites W2093869236 @default.
- W2092130014 cites W2098924804 @default.
- W2092130014 cites W2120625653 @default.
- W2092130014 cites W2154433130 @default.
- W2092130014 doi "https://doi.org/10.1002/glia.440040108" @default.
- W2092130014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1646766" @default.
- W2092130014 hasPublicationYear "1991" @default.
- W2092130014 type Work @default.
- W2092130014 sameAs 2092130014 @default.
- W2092130014 citedByCount "17" @default.
- W2092130014 countsByYear W20921300142012 @default.
- W2092130014 crossrefType "journal-article" @default.
- W2092130014 hasAuthorship W2092130014A5025292916 @default.
- W2092130014 hasAuthorship W2092130014A5027094294 @default.
- W2092130014 hasConcept C105702510 @default.
- W2092130014 hasConcept C126322002 @default.
- W2092130014 hasConcept C134018914 @default.
- W2092130014 hasConcept C150903083 @default.
- W2092130014 hasConcept C170493617 @default.
- W2092130014 hasConcept C192118531 @default.
- W2092130014 hasConcept C207001950 @default.
- W2092130014 hasConcept C2777499176 @default.
- W2092130014 hasConcept C2777542381 @default.
- W2092130014 hasConcept C2778900099 @default.
- W2092130014 hasConcept C2780884517 @default.
- W2092130014 hasConcept C2780912031 @default.
- W2092130014 hasConcept C515207424 @default.
- W2092130014 hasConcept C529278444 @default.
- W2092130014 hasConcept C55493867 @default.
- W2092130014 hasConcept C71924100 @default.
- W2092130014 hasConcept C86803240 @default.
- W2092130014 hasConcept C87555872 @default.
- W2092130014 hasConceptScore W2092130014C105702510 @default.
- W2092130014 hasConceptScore W2092130014C126322002 @default.
- W2092130014 hasConceptScore W2092130014C134018914 @default.
- W2092130014 hasConceptScore W2092130014C150903083 @default.
- W2092130014 hasConceptScore W2092130014C170493617 @default.
- W2092130014 hasConceptScore W2092130014C192118531 @default.
- W2092130014 hasConceptScore W2092130014C207001950 @default.
- W2092130014 hasConceptScore W2092130014C2777499176 @default.
- W2092130014 hasConceptScore W2092130014C2777542381 @default.
- W2092130014 hasConceptScore W2092130014C2778900099 @default.
- W2092130014 hasConceptScore W2092130014C2780884517 @default.
- W2092130014 hasConceptScore W2092130014C2780912031 @default.
- W2092130014 hasConceptScore W2092130014C515207424 @default.
- W2092130014 hasConceptScore W2092130014C529278444 @default.
- W2092130014 hasConceptScore W2092130014C55493867 @default.
- W2092130014 hasConceptScore W2092130014C71924100 @default.
- W2092130014 hasConceptScore W2092130014C86803240 @default.
- W2092130014 hasConceptScore W2092130014C87555872 @default.
- W2092130014 hasIssue "1" @default.
- W2092130014 hasLocation W20921300141 @default.
- W2092130014 hasLocation W20921300142 @default.
- W2092130014 hasOpenAccess W2092130014 @default.
- W2092130014 hasPrimaryLocation W20921300141 @default.
- W2092130014 hasRelatedWork W1972519976 @default.
- W2092130014 hasRelatedWork W1986341888 @default.
- W2092130014 hasRelatedWork W2071314483 @default.
- W2092130014 hasRelatedWork W2072353451 @default.
- W2092130014 hasRelatedWork W2076997169 @default.
- W2092130014 hasRelatedWork W2092130014 @default.
- W2092130014 hasRelatedWork W2109326550 @default.
- W2092130014 hasRelatedWork W2128322551 @default.
- W2092130014 hasRelatedWork W2155875957 @default.
- W2092130014 hasRelatedWork W2911607396 @default.
- W2092130014 hasVolume "4" @default.
- W2092130014 isParatext "false" @default.
- W2092130014 isRetracted "false" @default.
- W2092130014 magId "2092130014" @default.
- W2092130014 workType "article" @default.