Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092131498> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2092131498 endingPage "286" @default.
- W2092131498 startingPage "282" @default.
- W2092131498 abstract "Thirty patients with clinical and ambulatory essential hypertension were treated in a double-blind fashion with force titrated doses of placebo or diltiazem once daily (OD) extended-release (ER) 120, 240, 360, and 540 mg to characterize the full-dose range of the new formulation. An incremental dose-response effect was observed both in clinic and ambulatory blood pressure parameters. Doses of ≥240 mg significantly decreased clinic diastolic blood pressure, whereas systolic blood pressure was significantly lowered by the 540-mg dose. Moreover, compared with placebo, ambulatory blood pressure was significantly decreased by the 360- and 540-mg dose levels. Trough/peak ratios for systolic and diastolic blood pressures were 50% and higher at dose levels of 240 mg and above. Adverse reactions with diltiazem OD ER were generally mild and similar to those observed with placebo. The findings of this study indicate that the most favorable effects of diltiazem OD ER were observed in response to the 360- and 540-mg dose levels. The dose escalation forced titration study design appears to be a valuable tool in obtaining rigorous dose-response data of new antihypertensive agents. Am J Hypertens 1995;8:282–286" @default.
- W2092131498 created "2016-06-24" @default.
- W2092131498 creator A5001409903 @default.
- W2092131498 creator A5003871142 @default.
- W2092131498 creator A5044056736 @default.
- W2092131498 creator A5053731767 @default.
- W2092131498 date "1995-03-01" @default.
- W2092131498 modified "2023-09-30" @default.
- W2092131498 title "Clinical efficacy of force titrated doses of diltiazem extended-release a placebo controlled study" @default.
- W2092131498 cites W1509037851 @default.
- W2092131498 cites W165726118 @default.
- W2092131498 cites W1906843865 @default.
- W2092131498 cites W1963680344 @default.
- W2092131498 cites W1963773346 @default.
- W2092131498 cites W1982191861 @default.
- W2092131498 cites W1988758334 @default.
- W2092131498 cites W1989531273 @default.
- W2092131498 cites W2000567814 @default.
- W2092131498 cites W2051259398 @default.
- W2092131498 cites W2088457356 @default.
- W2092131498 cites W2092515303 @default.
- W2092131498 cites W2107816849 @default.
- W2092131498 cites W2142692525 @default.
- W2092131498 cites W2436961513 @default.
- W2092131498 cites W2729949319 @default.
- W2092131498 doi "https://doi.org/10.1016/0895-7061(94)00199-l" @default.
- W2092131498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7794578" @default.
- W2092131498 hasPublicationYear "1995" @default.
- W2092131498 type Work @default.
- W2092131498 sameAs 2092131498 @default.
- W2092131498 citedByCount "6" @default.
- W2092131498 crossrefType "journal-article" @default.
- W2092131498 hasAuthorship W2092131498A5001409903 @default.
- W2092131498 hasAuthorship W2092131498A5003871142 @default.
- W2092131498 hasAuthorship W2092131498A5044056736 @default.
- W2092131498 hasAuthorship W2092131498A5053731767 @default.
- W2092131498 hasConcept C126322002 @default.
- W2092131498 hasConcept C142724271 @default.
- W2092131498 hasConcept C149323552 @default.
- W2092131498 hasConcept C164705383 @default.
- W2092131498 hasConcept C197934379 @default.
- W2092131498 hasConcept C204787440 @default.
- W2092131498 hasConcept C27081682 @default.
- W2092131498 hasConcept C2776741139 @default.
- W2092131498 hasConcept C35785553 @default.
- W2092131498 hasConcept C42219234 @default.
- W2092131498 hasConcept C519063684 @default.
- W2092131498 hasConcept C57900726 @default.
- W2092131498 hasConcept C71924100 @default.
- W2092131498 hasConcept C84393581 @default.
- W2092131498 hasConcept C98274493 @default.
- W2092131498 hasConceptScore W2092131498C126322002 @default.
- W2092131498 hasConceptScore W2092131498C142724271 @default.
- W2092131498 hasConceptScore W2092131498C149323552 @default.
- W2092131498 hasConceptScore W2092131498C164705383 @default.
- W2092131498 hasConceptScore W2092131498C197934379 @default.
- W2092131498 hasConceptScore W2092131498C204787440 @default.
- W2092131498 hasConceptScore W2092131498C27081682 @default.
- W2092131498 hasConceptScore W2092131498C2776741139 @default.
- W2092131498 hasConceptScore W2092131498C35785553 @default.
- W2092131498 hasConceptScore W2092131498C42219234 @default.
- W2092131498 hasConceptScore W2092131498C519063684 @default.
- W2092131498 hasConceptScore W2092131498C57900726 @default.
- W2092131498 hasConceptScore W2092131498C71924100 @default.
- W2092131498 hasConceptScore W2092131498C84393581 @default.
- W2092131498 hasConceptScore W2092131498C98274493 @default.
- W2092131498 hasIssue "3" @default.
- W2092131498 hasLocation W20921314981 @default.
- W2092131498 hasLocation W20921314982 @default.
- W2092131498 hasOpenAccess W2092131498 @default.
- W2092131498 hasPrimaryLocation W20921314981 @default.
- W2092131498 hasRelatedWork W2015555924 @default.
- W2092131498 hasRelatedWork W2056758860 @default.
- W2092131498 hasRelatedWork W2153638346 @default.
- W2092131498 hasRelatedWork W2324123234 @default.
- W2092131498 hasRelatedWork W2350269752 @default.
- W2092131498 hasRelatedWork W2366855467 @default.
- W2092131498 hasRelatedWork W2414038239 @default.
- W2092131498 hasRelatedWork W2418295235 @default.
- W2092131498 hasRelatedWork W2471086114 @default.
- W2092131498 hasRelatedWork W41899294 @default.
- W2092131498 hasVolume "8" @default.
- W2092131498 isParatext "false" @default.
- W2092131498 isRetracted "false" @default.
- W2092131498 magId "2092131498" @default.
- W2092131498 workType "article" @default.