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- W2092133052 abstract "In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the influence of 7 beta-hydroxycholesteryl-3-oleate (oxysterol) on the intensity of the astrocytic reaction and the axonal regeneration. We have shown here that local administration of liposomes containing this oxysterol reduced the intensity of the astroglial reaction on the sectioned side, as seen with immunocytochemical detection of glial fibrillary acidic protein (GFAP) and by in situ hybridization with a specific RNA probe. Moreover, radioautographic evaluation of astrocyte proliferation with tritiated thymidine evidenced a reduction of the astrocyte labelling index. In addition, double immunocytochemical detection of GFAP and polysialylated neural cell adhesion molecule (E-NCAM) revealed a decrease of the expression of this molecule in reactive astrocytes of the treated animals. Finally, immunocytochemical detection of serotonin (5HT) was determined in the raphespinal projections, which constitute a major descending system. In treated animals, serotonergic axons originating from the intact side reinnervated the dorsal horn of the sectioned side, below the hemisection. These results demonstrate that 7 beta-hydroxycholesteryl-3-oleate can reduce the astrocytic reaction following spinal cord injury, promoting the serotonergic reinnervation of a denervated territory." @default.
- W2092133052 created "2016-06-24" @default.
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- W2092133052 date "1995-05-01" @default.
- W2092133052 modified "2023-09-25" @default.
- W2092133052 title "Oxystdrol (7β-hydroxycholestesteryl-3-oleate) promotes serotonergic reinnervation in the lesioned rat spinal cord by reducing glial reaction" @default.
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- W2092133052 cites W1592789336 @default.
- W2092133052 cites W1603255570 @default.
- W2092133052 cites W1880183951 @default.
- W2092133052 cites W1965677732 @default.
- W2092133052 cites W1966708225 @default.
- W2092133052 cites W1966985039 @default.
- W2092133052 cites W1968143827 @default.
- W2092133052 cites W1968244418 @default.
- W2092133052 cites W1971778712 @default.
- W2092133052 cites W1973434441 @default.
- W2092133052 cites W1975149550 @default.
- W2092133052 cites W1977640628 @default.
- W2092133052 cites W1982503110 @default.
- W2092133052 cites W1982641454 @default.
- W2092133052 cites W1986402652 @default.
- W2092133052 cites W1986586826 @default.
- W2092133052 cites W1987577484 @default.
- W2092133052 cites W1992479244 @default.
- W2092133052 cites W1992681847 @default.
- W2092133052 cites W1994315870 @default.
- W2092133052 cites W1995478060 @default.
- W2092133052 cites W1997531101 @default.
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- W2092133052 cites W2004313145 @default.
- W2092133052 cites W2006035115 @default.
- W2092133052 cites W2006809536 @default.
- W2092133052 cites W2010489002 @default.
- W2092133052 cites W2011387965 @default.
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- W2092133052 cites W2017613620 @default.
- W2092133052 cites W2023140033 @default.
- W2092133052 cites W2023402827 @default.
- W2092133052 cites W2027433066 @default.
- W2092133052 cites W2029505406 @default.
- W2092133052 cites W2031280774 @default.
- W2092133052 cites W2034761357 @default.
- W2092133052 cites W2037112388 @default.
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- W2092133052 cites W2050415048 @default.
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- W2092133052 cites W2054926970 @default.
- W2092133052 cites W2058017456 @default.
- W2092133052 cites W2058397444 @default.
- W2092133052 cites W2066858262 @default.
- W2092133052 cites W2068663798 @default.
- W2092133052 cites W2070942720 @default.
- W2092133052 cites W2077630079 @default.
- W2092133052 cites W2080885465 @default.
- W2092133052 cites W2081535042 @default.
- W2092133052 cites W2082609393 @default.
- W2092133052 cites W2084728059 @default.
- W2092133052 cites W2090169119 @default.
- W2092133052 cites W2091034459 @default.
- W2092133052 cites W2095418009 @default.
- W2092133052 cites W2116181102 @default.
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- W2092133052 cites W2139617720 @default.
- W2092133052 cites W2148133676 @default.
- W2092133052 cites W2154021054 @default.
- W2092133052 cites W2155520053 @default.
- W2092133052 cites W2167251354 @default.
- W2092133052 cites W4239750298 @default.
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- W2092133052 doi "https://doi.org/10.1002/jnr.490410110" @default.
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- W2092133052 hasPublicationYear "1995" @default.
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