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• W2092134704 abstract "The sphingolipids, sphingosine (SPH), sphingosylphosphorylcholine (SPC) and psycosine induce a rapid and transient rise in nuclear free Ca2+concentration in a dose dependent manner. To determine whether these sphingolipids act by a IP3-dependent pathway, we tested the increase of Ca2+in the presence of heparin, an antagonist of IP3receptor or U70122, an inhibitor of phospholipase C. Results indicate that the effect of both SPH and SPC, but not that of psychosine, is partially mediated by IP3production. The sphingolipid-induced Ca2+mobilization was unaffected by the inhibition of protein kinase C, but was totally abolished in the presence of nimodipine, a L-type Ca2+channel inhibitor. The results could indicate the existence of a sphingosine-gated Ca2+-permeable channel in liver nuclei." @default.
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• W2092134704 date "1997-09-01" @default.
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• W2092134704 title "Sphingolipids Increase Calcium Concentration in Isolated Rat Liver Nuclei" @default.
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• W2092134704 doi "https://doi.org/10.1006/bbrc.1997.7302" @default.
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