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- W2092136601 endingPage "550" @default.
- W2092136601 startingPage "550" @default.
- W2092136601 abstract "Ischaemia reperfusion injury is a common and important phenomenon that occurs predictably in patients undergoing such procedures as cardiopulmonary bypass, thrombolysis, surgery under tourniquet, organ transplantation or embolectomy. Oxidative stress and the resulting lipid peroxidation play a major role in reperfusion injury. Membrane and cellular dysfunction result and, subsequently, organ injury or failure may ensue. Traditional methods of quantifying ischaemia reperfusion injury, including measurement of malondialdehyde, lack specificity and sensitivity. It was reported in 1990 that isoprostanes, a series of prostaglandin-like compounds, are produced by the free radical-catalyzed peroxidation of arachidonic acid. Measurement of the isoprostane concentration in urine or plasma provides the most reliable, non-invasive method currently available to assess oxidative stress in vivo. Serial measurement of isoprostanes in biological fluids has enhanced our understanding of the mechanisms underlying ischaemia reperfusion injury itself and its role in certain diseases. Furthermore, measurement of the isoprostane concentration provides a means to assess the effects of prophylactic and therapeutic interventions. In the future, the development of rapid, simple assays for isoprostanes offers the potential to assess prognosis during and after ischaemia reperfusion events." @default.
- W2092136601 created "2016-06-24" @default.
- W2092136601 creator A5043118145 @default.
- W2092136601 creator A5074941192 @default.
- W2092136601 creator A5076037429 @default.
- W2092136601 creator A5091498476 @default.
- W2092136601 date "2002-08-01" @default.
- W2092136601 modified "2023-09-25" @default.
- W2092136601 title "Isoprostanes – markers of ischaemia reperfusion injury" @default.
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