FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092139627> ?p ?o ?g. }

• W2092139627 endingPage "177" @default.
• W2092139627 startingPage "172" @default.
• W2092139627 abstract "Despite rapid dissolution in compendial phosphate buffers, gastro resistant (enteric coated) products can take up to 2 h to disintegrate in the human small intestine, which clearly highlights the inadequacy of the in vitro test method to predict in vivo behaviour of these formulations. The aim of this study was to establish the utility of a novel pH 5.6 bicarbonate buffer, stabilized by an Auto pH™ System, as a better surrogate of the conditions of the proximal small intestine to investigate the dissolution behaviour of standard and accelerated release enteric double coating formulations. Prednisolone tablets were coated with 3 or 5 mg/cm2 of partially neutralized EUDRAGIT® L 30 D-55, HP-55 or HPMC adjusted to pH 6 or 8. An outer layer of EUDRAGIT® L 30 D-55 was applied at 5 mg/cm2. For comparison purposes, a standard single layer of EUDRAGIT® L 30 D-55 was applied to the tablets. Dissolution was carried out using USP II apparatus in 0.1 M HCl for 2 h, followed by pH 5.6 bicarbonate buffer. EUDRAGIT® L 30 D-55 single-coated tablets showed a slow drug release with a lag time of 75 min in buffer, whereas release from the EUDRAGIT® L 30 D-55 double-coated tablets was accelerated. These in vitro lag times closely match the in vivo disintegration times for these coated tablets reported previously. Drug release was further accelerated from modified double coatings, particularly in the case of coatings with a thinner inner layer of HP-55 or HPMC (pH 8 and KH2PO4). This study confirms that the pH 5.6 bicarbonate buffer system offers significant advantages during the development of dosage forms designed to release the drug in the upper small intestine." @default.
• W2092139627 created "2016-06-24" @default.
• W2092139627 creator A5005594065 @default.
• W2092139627 creator A5009837057 @default.
• W2092139627 creator A5020162492 @default.
• W2092139627 creator A5023267784 @default.
• W2092139627 creator A5031888549 @default.
• W2092139627 creator A5077680140 @default.
• W2092139627 date "2014-07-01" @default.
• W2092139627 modified "2023-09-24" @default.
• W2092139627 title "Accelerating the dissolution of enteric coatings in the upper small intestine: Evolution of a novel pH 5.6 bicarbonate buffer system to assess drug release" @default.
• W2092139627 cites W1535579925 @default.
• W2092139627 cites W1546050977 @default.
• W2092139627 cites W1975103091 @default.
• W2092139627 cites W1977750336 @default.
• W2092139627 cites W1981602515 @default.
• W2092139627 cites W1982862993 @default.
• W2092139627 cites W1983492645 @default.
• W2092139627 cites W1987028317 @default.
• W2092139627 cites W1988261154 @default.
• W2092139627 cites W1990432963 @default.
• W2092139627 cites W1997106286 @default.
• W2092139627 cites W2001488324 @default.
• W2092139627 cites W2007250371 @default.
• W2092139627 cites W2017678349 @default.
• W2092139627 cites W2024242548 @default.
• W2092139627 cites W2024443377 @default.
• W2092139627 cites W2049460800 @default.
• W2092139627 cites W2058005106 @default.
• W2092139627 cites W2072565752 @default.
• W2092139627 cites W2079163881 @default.
• W2092139627 cites W2088382816 @default.
• W2092139627 cites W2095179999 @default.
• W2092139627 cites W2112336067 @default.
• W2092139627 cites W2117932143 @default.
• W2092139627 cites W2143363925 @default.
• W2092139627 cites W287350518 @default.
• W2092139627 doi "https://doi.org/10.1016/j.ijpharm.2014.04.019" @default.
• W2092139627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24727141" @default.
• W2092139627 hasPublicationYear "2014" @default.
• W2092139627 type Work @default.
• W2092139627 sameAs 2092139627 @default.
• W2092139627 citedByCount "26" @default.
• W2092139627 countsByYear W20921396272014 @default.
• W2092139627 countsByYear W20921396272015 @default.
• W2092139627 countsByYear W20921396272016 @default.
• W2092139627 countsByYear W20921396272017 @default.
• W2092139627 countsByYear W20921396272018 @default.
• W2092139627 countsByYear W20921396272019 @default.
• W2092139627 countsByYear W20921396272020 @default.
• W2092139627 countsByYear W20921396272021 @default.
• W2092139627 countsByYear W20921396272022 @default.
• W2092139627 countsByYear W20921396272023 @default.
• W2092139627 crossrefType "journal-article" @default.
• W2092139627 hasAuthorship W2092139627A5005594065 @default.
• W2092139627 hasAuthorship W2092139627A5009837057 @default.
• W2092139627 hasAuthorship W2092139627A5020162492 @default.
• W2092139627 hasAuthorship W2092139627A5023267784 @default.
• W2092139627 hasAuthorship W2092139627A5031888549 @default.
• W2092139627 hasAuthorship W2092139627A5077680140 @default.
• W2092139627 hasConcept C13965031 @default.
• W2092139627 hasConcept C14029885 @default.
• W2092139627 hasConcept C145018004 @default.
• W2092139627 hasConcept C150903083 @default.
• W2092139627 hasConcept C178790620 @default.
• W2092139627 hasConcept C185592680 @default.
• W2092139627 hasConcept C207001950 @default.
• W2092139627 hasConcept C2777570183 @default.
• W2092139627 hasConcept C2778117296 @default.
• W2092139627 hasConcept C2781112554 @default.
• W2092139627 hasConcept C2781430271 @default.
• W2092139627 hasConcept C41008148 @default.
• W2092139627 hasConcept C43617362 @default.
• W2092139627 hasConcept C76155785 @default.
• W2092139627 hasConcept C77281830 @default.
• W2092139627 hasConcept C86803240 @default.
• W2092139627 hasConcept C88380143 @default.
• W2092139627 hasConceptScore W2092139627C13965031 @default.
• W2092139627 hasConceptScore W2092139627C14029885 @default.
• W2092139627 hasConceptScore W2092139627C145018004 @default.
• W2092139627 hasConceptScore W2092139627C150903083 @default.
• W2092139627 hasConceptScore W2092139627C178790620 @default.
• W2092139627 hasConceptScore W2092139627C185592680 @default.
• W2092139627 hasConceptScore W2092139627C207001950 @default.
• W2092139627 hasConceptScore W2092139627C2777570183 @default.
• W2092139627 hasConceptScore W2092139627C2778117296 @default.
• W2092139627 hasConceptScore W2092139627C2781112554 @default.
• W2092139627 hasConceptScore W2092139627C2781430271 @default.
• W2092139627 hasConceptScore W2092139627C41008148 @default.
• W2092139627 hasConceptScore W2092139627C43617362 @default.
• W2092139627 hasConceptScore W2092139627C76155785 @default.
• W2092139627 hasConceptScore W2092139627C77281830 @default.
• W2092139627 hasConceptScore W2092139627C86803240 @default.
• W2092139627 hasConceptScore W2092139627C88380143 @default.
• W2092139627 hasIssue "1-2" @default.
• W2092139627 hasLocation W20921396271 @default.
• W2092139627 hasLocation W20921396272 @default.
• W2092139627 hasOpenAccess W2092139627 @default.

• next