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- W2092143207 abstract "In 1900, Oppenheim1described 8 patients who had a nonfamilial present at birth characterized by hypotonia, absent deep tendon reflexes, and muscular weakness, that gradually improved with age. Oppenheim postulated that this was the result of a temporary abnormality of muscle. Eight years later, Collier and Wilson2gave this the name amyotonia congenita. Subsequently, because of reputation on the Continent, almost all cases of hypotonia unexplainable by some other specific were designated as instances of Oppenheim's disease or amyotonia congenita. Oppenheim had no pathological confirmation that the condition he described was different from other conditions causing hypotonia, and, in fact, subsequent investigations3-4have proved that the pathology of many cases of amyotonia congenita is the same as that of Werdnig-Hoffmann's disease, namely a degeneration of anterior horn cells of the spinal cord. It appears likely that various diseases have been grouped under" @default.
- W2092143207 created "2016-06-24" @default.
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- W2092143207 date "1961-04-01" @default.
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- W2092143207 title "The Floppy Infant" @default.
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- W2092143207 doi "https://doi.org/10.1001/archpedi.1961.04020050115018" @default.
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